Abstract
Background: A genetic syndrome associated with schizophrenia, 22q11 deletion syndrome
(22qDS), may represent a genetic subtype of schizophrenia (22qDS-Sz). Structural brain
changes are common in schizophrenia and may involve developmental anomalies, but there
are no data yet for 22qDS-Sz. The objective of this study was to assess brain structure
in adults with 22qDS-Sz using magnetic resonance imaging (MRI).
Methods: Brain and arterial MRI scans of 11 adults with 22qDS-Sz (mean age = 28.4
years, SD = 6.5) were systematically assessed by a neuroradiologist for qualitative
anomalies.
Results: A high frequency of abnormalities were found: T2 white matter bright foci
(BF), 90%; developmental midline anomalies, 45%; cerebral atrophy or ventricular enlargement,
54%; mild cerebellar atrophy, 36%; skull base abnormalities, 55%; and minor vascular
abnormalities, 36%.
Conclusions: BF and skull base abnormalities, especially in association with neurodevelopmental
midline abnormalities, may be distinguishing MRI features for a genetic subtype of
schizophrenia involving a deletion on chromosome 22.
Keywords
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Article info
Publication history
Accepted:
June 2,
1999
Received in revised form:
May 26,
1999
Received:
February 25,
1999
Identification
Copyright
© 1999 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
