Abstract
Background: We had previously reported a decrease in agonist-induced platelet dense
granule secretion in blood samples from male adolescents with and without Conduct
Disorder (CD). In an augmented sample, we have now employed multivariate modeling
to examine the simultaneous effects of CD and regular monthly alcohol and marijuana
use on both the dense granule secretion and aggregation phases of agonist-induced
platelet responses.
Methods: Blood samples were obtained from adolescents with and without a CD diagnosis.
Platelet dense granule secretion and aggregation responses to a variety of agonists
were examined in the laboratory.
Results: Significant multivariate interactions of CD status with regular marijuana
use were found for responses to collagen, ADP alone, and ADP plus 0.2 μg. of serotonin.
Responses in platelets from youth with CD, but without regular marijuana use differed
from other subjects. Multivariate main effects of marijuana use alone on platelet
responses to arachidonic acid and ADP plus 1.0 μg. of serotonin were found. No effects
of alcohol use were found.
Conclusions: The results demonstrate an interaction between CD and the effects of
chronic marijuana use for several agonists in this platelet model system, and further
support the possibility of a variation in signal transduction mechanisms in CD.
Keywords
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References
- Limitations of the application of fourfold table analysis to hospital data.Biometrics. 1946; 2: 47-53
- Quantitation of platelet mass during aggregation in the electronic (Wellcome) Whole Blood Aggregometer.J Pharmacol Methods. 1982; 8: 115-122
- Platelet receptors.Hematol Oncol Clin North Am. 1990; 4: 27-42
- Crime and Personality. 3rd ed. Routledge and Kegan, London1977
- The lumi-aggregometer as a research tool and clinical tool.in: Longnecker G The Platelets Physiology and Pharmacology. Academic Press Inc, Orlando1985: 429-440
- The inhibitory effects of cannabinoids, the active constituents of Cannabis sativa L. on human and rabbit platelet aggregation.J Pharm Pharmacol. 1989; 41: 705-709
- The three arousal model.Psychophysiology. 1980; 17: 87-104
- Psychopathy. Theory and research. John Wiley & Sons, New York1970
- A quick method for screening platelet dysfunctions using the whole blood lumi-aggregometer.Thromb Haemostas. 1984; 51: 154-156
- Urinary catecholamines, stress, and psychopathy.Psychosom Med. 1978; 40: 116-125
- G proteins.Am J Psychiatry. 1992; 149: 746-760
- Patterns of DSM-IV alcohol abuse and dependence symptoms in adolescent drinkers.J Stud Alcohol. 1995; 56: 672-680
- Assessment of binding indices and physiological responsiveness of the 5-HT2 receptor on human platelets.Life Sci. 1987; 40: 1799-1809
- [31P] Magnetic resonance brain spectroscopy of children at-risk for a substance use disorder.Psychiatry Res. 1997; 76: 101-112
- Salivary cortisol responses and the risk for substance abuse in prepubertal boys.Biol Psychiatry. 1995; 38: 547-555
- Salivary cortisol responses in prepubertal boys.Biol Psychiatry. 1999; 45: 1293-1299
- Platelet dense granule secretion in adolescents with conduct disorder and substance abuse.Biol Psychiatry. 1996; 40: 892-898
- Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse.Biol Psychiatry. 1990; 28: 325-338
- Introduction.in: Wyngaarden J.B Smith L.H Cecil Textbook of Medicine. W.B. Saunders, Philadelphia1988: 873-878
- Electrodermal and cardiovascular evidence of a coping response in psychopaths.Criminal Justice Behav. 1990; 17: 231-245
- Retrospective assessment of prepubertal major depression with the Kiddie-SADS-E.J Am Acad Child Adol Psychiatry. 1982; 21: 392-397
- Platelet activation and inhibition. Novel signal transduction mechanisms.Ann NY Acad Sci. 1994; 714: 53-63
- Platelet serotonin 2A (5-HT2A) receptor characteristics and parenting factors for boys at risk for delinquency.Am J Psychiatry. 1996; 153: 538-544
- Critical evaluation of platelet aggregation in whole human blood.Am J Clin Pathol. 1986; 85: 50-56
- Effects of ethanol on platelets.Lab Invest. 1990; 63: 729-732
- Alcohol and platelet function.Alcohol Clin Exp Res. 1994; 18: 105-110
- Decreased platelet aggregation following marijuana smoking in man.J Okla State Med Assoc. 1979; 72: 435-436
Spitzer R., Williams B, Gibbons M. (1987): Instruction Manual for the Structured Clinical Interview for DSM-III-R (SCID, 4/1/87 Revision). New York: Biometrics Research Department, NYS Psychiatric Institute.
- Withdrawal and dependency symptoms among adolescent alcohol and drug abusers.Addiction. 1995; 90: 627-635
- Using Multivariate Statistics. Third Edition. Harper Collins College Publishers, New York1996: 412
- Evaluation and treatment of adolescent substance abuse.Am J Drug Alcohol Abuse. 1990; 16: 1-46
- Antisocial symptoms in preadolescent boys and their parents.Psychiatric Res. 1993; 46: 9-17
- Differential expression of guanosine triphosphate binding proteins in men at high and low risk for the future development of alcoholism.J Clin Invest. 1994; 94: 1004-1011
Article info
Publication history
Accepted:
April 27,
1999
Received in revised form:
February 1,
1999
Received in revised form:
April 26,
1999
Received:
November 30,
1998
Identification
Copyright
© 1999 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
