Abstract
Background: The neuroanatomic and pathologic basis of Tourette’s syndrome or related
disorders such as obsessive-compulsive disorder and attention deficit-hyperactivity
disorder remains unknown. Although a substantial body of neuroimaging and other data
implicate basal ganglia and some point out specifically the globus pallidus in the
etiopathogenesis of these three related disorders, no clear or pathologically significant
isolated lesions restricted to this region have yet been demonstrated, with the exception
of obsessive-compulsive disorder.
Methods: A seventeen-year-old male case of Tourette syndrome with comorbid obsessive-compulsive
disorder, attention deficit-hyperactivity disorder, stuttering and gait disturbance,
who had negative family history is presented.
Results: The patient has failed to respond to drug treatment and his MRI scan revealed
bilateral and symmetrical globus pallidus lesions with specific “tiger’s eye” appearance
of unknown etiology.
Conclusions: Well-localized lesions in the globus pallidus support growing data suggesting
the involvement of this brain region in Tourette syndrome and related disorders.
Keywords
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Article info
Publication history
Accepted:
March 29,
1999
Received in revised form:
March 4,
1999
Received:
January 12,
1999
Identification
Copyright
© 1999 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
