Abstract
Background: Down syndrome (DS) is a genetic disorder (trisomy 21 in 96% of cases),
associated with an excess of a key enzyme involved with free radical metabolism (FRM),
superoxide dismutase-1 (SOD-1), that is encoded by a gene on chromosome 21. Consequently,
SOD-1 activity is elevated in DS, which also occurs in conditions of oxidative stress,
and is associated with a compensatory increase in glutathione peroxidase activity
(GSHPx).
Methods: This study examined the relationship of memory function with erythrocyte
SOD-1, GSHPx and catalase (CAT) activity in 22–51 year old adults with DS.
Results: Mean erythrocyte SOD-1 (p < .02) and GSHPx (p < .01), but not CAT (p = .76), activities were significantly greater in the DS group than the controls.
In the DS group, erythrocyte GSHPx, but not SOD-1 or CAT activities, was significantly
correlated with memory function (r = .625, p < .025, df = 13 for savings score, r = .631, p < .01, df = 14 for intrusion errors) but not with intelligence quotients.
Conclusions: These observations suggest a possible relationship between altered FRM
with memory deficits among adults with DS within the age-range in that an age-related
increase in the prevalence for Alzheimer’s neuropathology is known to be robust before
reaching a plateau of 100%.
Keywords
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Article info
Publication history
Accepted:
January 22,
1999
Received in revised form:
January 18,
1999
Received:
April 27,
1998
Identification
Copyright
© 1999 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
