Abstract
Background: Voltage of the P300 component of event-related potentials (ERPs) has been
proposed as a phenotypic marker of risk for alcoholism. P3a elicited by intrusive
events is important in the context of deficits in inhibition found during psychophysiological
and behavioral evaluations in children of alcoholics.
Methods: ERPs were recorded from a group of adult children of alcoholics (n = 26) and controls (n = 23) with a three-stimulus visual oddball paradigm. The task required a difficult
perceptual discrimination between a frequent (.80) vertical line and an infrequent
(.10) 2° tilted line (target). An easily discriminable nontarget infrequent horizontal
line also occurred (.10). Subjects were required to press a button to the target.
P3a was compared using mixed-model ANCOVAs at 31 sites organized in 5 scalp regions.
Current source density (CSD) maps were also analyzed.
Results: High-risk (HR) subjects manifested reduced P3a amplitudes compared to controls
at frontal, central, parietal, and temporal electrodes. CSD analyses supported these
findings with group differences found for all the scalp regions.
Conclusions: The results are discussed in relation to previous HR studies. P3a reductions
may be related to deficits in neuronal inhibition during stimulus processing. These
results suggest that P3a amplitude may be important as a marker for vulnerability
to alcoholism.
Keywords
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Article info
Publication history
Accepted:
July 20,
1998
Received in revised form:
July 10,
1998
Received:
January 2,
1998
Identification
Copyright
© 1999 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
