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Sleep-disordered breathing and periodic limb movements in sleep in older patients with schizophrenia

  • Sonia Ancoli-Israel
    Correspondence
    Address reprint requests to Ancoli-Israel, PhD, Department of Psychiatry 116A, San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161 USA
    Affiliations
    Department of Psychiatry, University of California, San Diego and the San Diego Veterans Affairs Healthcare System (SA-I, DWJ, MC, TP, MJH, DVJ), San Diego, California USA
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  • Jennifer Martin
    Affiliations
    San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology (JM), San Diego, California USA
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  • Denise W Jones
    Affiliations
    Department of Psychiatry, University of California, San Diego and the San Diego Veterans Affairs Healthcare System (SA-I, DWJ, MC, TP, MJH, DVJ), San Diego, California USA
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  • Michael Caligiuri
    Affiliations
    Department of Psychiatry, University of California, San Diego and the San Diego Veterans Affairs Healthcare System (SA-I, DWJ, MC, TP, MJH, DVJ), San Diego, California USA
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  • Thomas Patterson
    Affiliations
    Department of Psychiatry, University of California, San Diego and the San Diego Veterans Affairs Healthcare System (SA-I, DWJ, MC, TP, MJH, DVJ), San Diego, California USA
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  • M.Jackuelyn Harris
    Affiliations
    Department of Psychiatry, University of California, San Diego and the San Diego Veterans Affairs Healthcare System (SA-I, DWJ, MC, TP, MJH, DVJ), San Diego, California USA
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  • Dilip V Jeste
    Affiliations
    Department of Psychiatry, University of California, San Diego and the San Diego Veterans Affairs Healthcare System (SA-I, DWJ, MC, TP, MJH, DVJ), San Diego, California USA
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      Abstract

      Background: Since the prevalence of both sleep-disordered breathing (SDB) and periodic limb movements in sleep (PLMS) increase with age, we explored whether older schizophrenia patients would have a high incidence of SDB and PLMS. Correlations between sleep and clinical variables were also examined.
      Methods: Fifty-two patients (mean age = 59.6 years, SD = 8.9) had their sleep/wake, respiration, and leg movements recorded using a modified Medilog/Respitrace portable recording system plus oximetry. A battery of clinical, psychosocial, and motor disturbance variables were collected by research center staff.
      Results: Forty-eight percent of these patients had at least 10 respiratory events per hour of sleep. These patients reported more symptoms of daytime sleepiness than patients with fewer than 10 events per hour. The relatively high prevalence of SDB in this group may contribute to overall sleep disturbances, and does not appear to be a result of high body mass index. Only 14% of the patients had at least five limb movements per hour of sleep, suggesting the prevalence of PLMS is much lower than expected in this age group. The number of leg jerks was inversely related to symptoms of tardive dyskinesia.
      Conclusions: The disturbance of sleep in these patients may be due, in part, to SDB, but is unlikely due to PLMS.

      Keywords

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