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Modafinil: An antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers

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      References

        • Bastuji H
        • Jouvet M
        Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil.
        Prog Neuropsychopharmacol Biol Psychiatry. 1988; 12: 695-700
        • Ferraro L
        • Tanganelli S
        • O'Connor WT
        • Antonelli T
        • Rambert F
        • Fuxe K
        The vigilance promoting drug modafinil decreases GABA release in the medial preoptic area and the posterior hypothalamus of the awake rat: Possible involvement of the serotonergic 5-HT3 receptor.
        Neurosci Lett. 1996; 220: 5-8
        • Ferraro L
        • Tanganelli S
        • O'Connor WT
        • Antonelli T
        • Rambert F
        • Fuxe K
        The vigilance promoting drug modafinil increases dopamine release in the rat nucleus accumbens via the involvement of a local GABAergic mechanism.
        Eur J Pharmacol. 1996; 306: 33-39
        • Fuxe K
        • Rambert FA
        • Ferraro L
        • O'Connor WT
        • Laurent P
        • Agnati LF
        Preclinical studies with modafinil.
        Drugs Today. 1996; 32: 313-326
        • Koob GF
        • Bloom FE
        Cellular and molecular mechanisms of drug dependence.
        Science. 1988; 242: 715-723
        • Morari M
        • O'Connor WT
        • Ungerstedt U
        • Fuxe K
        NMDA differently regulates extracellular dopamine, GABA and glutamate levels in the dorsolateral neostriatum of the halothane anaesthetized rat: An in vivo microdialysis study.
        J Neurochem. 1993; 60: 1884-1893
        • Rambert FA
        • Pessonnier J
        • Duteil J
        Modafinil-, amphetamine- and methylphenidate-induced hyperactivities in mice involve different mechanisms.
        Eur J Pharmacol. 1990; 183: 455-456
        • Santiago M
        • Westerink BHC
        The role of GABA receptors in the control of nigrostriatal dopaminergic neurons: Dual-probe microdialysis study in awake rats.
        Eur J Pharmacol. 1992; 219: 175-181
        • Sharp T
        • Zetterstrom T
        • Ljungberg T
        • Ungerstedt U
        A direct comparison of amphetamine-induced behaviours and regional brain dopamine release in the rat using intracerebral dialysis.
        Brain Res. 1987; 401: 322-330