Fine structural alterations of blood platelets in depression

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      1. (Translated by Pierre Pichot)
        • American Psychiatric Association
        Diagnostic and Statistical Manual of Mental Disorders.
        3rd ed rev. Masson, New York1989
        • Coppen A
        Role of serotonin in affective disorders.
        in: Barchas J Usdin E Serotonin and Behaviour. Academic Press, Barcelona1972: 523-527
        • Coppen A
        • Swade C
        • Wood K
        Platelet 5-hydroxytriptamine accumulation in depressive illness.
        Clin Chem Acta. 1978; 87: 165-168
        • Da Prada M
        • Cesura AM
        • Launay JM
        • Richards JG
        Platelets as model for neurons.
        Experientia. 1988; 44: 115-126
        • David-Ferreira JF
        Electron microscopic studies.
        Int Rev Cytol. 1964; 17: 99-148
        • Ebbeling L
        • Robertson C
        • McNicol A
        • Gerrard JM
        Rapid ultrastructural changes in the dense tubular system following platelet activation.
        Blood. 1992; 80: 718-723
        • Ingerman C
        • Smith B
        • Shapiro S
        • Sedar A
        • Silver M
        Hereditary abnormality of platelet aggregation attributable nucleotide storage pool deficiency.
        Blood. 1978; 52: 332-344
        • Lesch KP
        • Gross J
        • Franzek E
        • Wolozin BL
        • Riederer P
        • Murphy DL
        Primary structure of the serotonin transporter in unipolar depression and bipolar depression.
        Biol Psychiatry. 1995; 37: 215-223
        • Lingjaerde O
        Blood platelets as a model system for studying serotonergic dysfunctions and effects of antidepressants.
        Pharmacol Toxicol. 1990; 66: 61-68
        • Maas J
        • Huang Y
        Noradrenergic function and depression, too much or too little?.
        J Can Sci Neurol. 1980; 7: 267-268
        • Meltzer HY
        Role of serotonin in depression.
        Ann NY Acad Sci. 1990; 600: 486-500
        • Modai I
        • Zemishlany Z
        • Jerushalmy Z
        5-hydroxytriptamine uptake by blood platelets of unipolar and bipolar depressed patients.
        Neuropsychobiology. 1984; 12: 93-95
        • Mück-Seler D
        • Jakovljevic M
        • Pivac N
        Platelet 5-HT concentrations and suicidal behaviour in recurrent major depression.
        J Affect Disord. 1996; 39: 73-80
        • Owens MJ
        • Nemeroff CB
        Role of serotonin in the pathophysiology of depression: Focus on the serotonin transporter.
        Clin Chem. 1994; 40: 288-295
        • Pletsher A
        Platelet as models: Use and limitations.
        Experientia. 1988; 44: 152-155
        • Risch SC
        • Nemeroff CB
        Neurochemical alterations of serotonergic neuronal systems in depression.
        J Clin Psychiatry. 1992; 53: 3-7
        • Spatz H
        • Spatz N
        Platelet serotonin in endogenous depressive patients and normal controls.
        Acta Psiquiatr Psicol Am Lat. 1995; 41: 230-236
        • Wirt-Justice A
        Platelet research in psychiatry.
        Experientia. 1988; 44: 145-152