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Indirect observations suggest that the dopaminergic system may be involved in the
pathophysiology of obsessive—compulsive disorder (OCD). The dopaminergic function
of 15 patients with OCD and 15 age/sex-matched controls was evaluated by measuring
the growth hormone (GH) responses to stimulation with the dopaminergic agonist apomorphine
(APO), which increases growth hormone-releasing hormone (GHRH), GH, and somatomedine
C (SMD-C) secretions. Therefore, we measured basal plasma GH and SMD-C concentrations
and GH responses to GHRH stimulation to exclude that a downstream pathology of the
somatotropic axis could obscure the significance of the results of the APO test. The
response of prolactin (PRL) to APO inhibition were also measured. Basal plasma levels
of GH, SMD-C, and PRL, GH responses to GHRH stimulation, and PRL responses to APO
inhibition did not differ in the two groups of subjects. GH responses to APO stimulation
were blunted in obsessive—compulsive (OC) patients. The emetic response to the same
stimulation was stronger in patients than in controls. These responses suggest that
in our OC patients there is a dysregulation of the dopaminergic system, which is possibly
expressed in different ways in the various areas of the central nervous system.
Key Words
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Article info
Publication history
Received in revised form:
October 2,
1996
Received:
June 10,
1996
Identification
Copyright
© 1997 Society of Biological Psychiatry. Published by Elsevier Inc.
