This paper is only available as a PDF. To read, Please Download here.
To study the relationships between clinical and biological data that are necessary
for physiopathological analysis in the field of developmental disorders, we developed
a quantified grouping system, based on four developmental assessment parameters. Parallel
with this clinical research, we developed electrophysiological procedures adapted
to the pathology of autism. In this paper, we report the utilization of an original
multivariate descriptive statistical approach (correspondence analysis followed by
cluster analysis) that allowed us to identify different bioclinical profiles using
these clinical and electrophysiological data conjointly. These profiles are believed
to be evidence for different underlying cerebral dysfunctions. This procedure proved
effective in identifying two main bioclinical dimensions in a population of 145 developmentally
disordered children. These dimensions reflect the association of intellectual impairment
and centroparietal electrophysiological reactivity on the one hand, and autistic behavior
and temporal electrophysiological reactivity on the other. This study, performed on
a large population of children using objective methods of data analysis, provides
validation of numerous multidisciplinary studies of autism and other developmental
disorders carried out on small samples of children.
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Use of bioclinical markers for the assessment and treatment of children with pervasive developmental disorders.Biol Psychiatry. 1989; 22: 117-124
- Diagnostic and Statistical Manual of Mental Disorders.3rd ed rev. American Psychiatric Press, Norwalk1987
- Click evoked EEG responses in normal and developmentally retarded infants.Nature. 1967; 214: 252-255
- Clinical, biological and therapeutic applications of the functional analysis of autistic disorders.Brain Dysfunct. 1990; 3: 271-284
- 1 Validation of the revised Behavior Summarized Evaluation scale (BSE-R).J Autism Dev Disord. 1997; 27: 137-151
- Statistical analysis as a tool to make patterns emerge from data.in: Watanabe S Methodologies of Pattern Recognition. Academic Press, Washington, DC1969: 35-74
- L'analyse des données, Tome I: La Taxinomie, Tome II: L'Analyse des Correspondances.Dunod, New York1973
- Frontal auditory evoked potentials and augmenting-reducing.Electroencephalogr Clin Neurophysiol. 1985; 62: 364-371
- (EEG suppl 40)Modulation of auditory evoked potentials with increasing stimulus intensity in autistic children.in: Johnson RJ Parasuraman R Rohrbaugh JW Current Trends in Event-Related Potential Research. Elsevier, Paris1987: 584-589
- Clinical, electrophysiological, and biochemical markers and monoaminergic hypotheses in autism.in: Rothenberger A Brain and Behavior in Child Psychiatry. Springer International, Amsterdam1990: 217-234
- Temporal prominence of auditory evoked potentials in 4-8-year-old children.Psychophysiology. 1997; 34: 32-38
- Le développement psychologique de la première enfance.5th ed. Editions scientifiques et phychologiques, Berlin1983
- Psychopharmacology of Autism.Utrecht. 1991;
- Diagnostic criteria and behavior patterns in infantile autism.Psychopharmacol Bull. 1989; 25: 194-197
- Pathophysiologic findings in nonretarded autism and receptive developmental language disorder.J Autism Dev Disord. 1989; 19: 1-17
- Atypical development: DSMIII and the pervasive developmental disorders of early onset.J Am Acad Child Psychiatry. 1986; 26: 170-180
- Reduced P3 amplitude of the event-related brain potential: Its relationship to language ability in autism.J Autism Dev Disord. 1988; 18: 493-504
- Subtypes of autism by cluster analysis.J Autism Dev Disord. 1994; 24: 3-22
- Cognitive subtypes in developmentally disabled children: A pilot study.J Autism Dev Disord. 1985; 15: 77-95
- Visual evoked potentials of mildly mentally retarded and control children.Dev Med Child Neurol. 1988; 30: 638-645
- Developmental Diagnosis. Normal and Abnormal Child Development: Clinical Methods and Pediatric Applications.PB Hoeber, Issy les Moulineaux1947
- Quantified multidimensional assessment of autism and other pervasive developmental disorders.Eur Child Adolesc Psychiatry. 1995; 4: 123-135
- Trypanosomiase: Détermination de groupes de patients à partir de données cliniques et électroencéphalographiques.Neurophysiol Clin. 1995; 25: 196-202
- Correspondence analysis: Graphical representation of categorical data in marketing research.J Marketing Res. 1986; 23: 213-227
- Multivariate Descriptive Statistical Analysis: Correspondence Analysis and Related Techniques for Large Matrices.Wiley, New York1984
- Comparative study of conditioning of averaged evoked responses by coupling sound and light in normal and autistic children.Psychophysiology. 1973; 10: 415-427
- Free acquisition, free imitation, physiological curiosity and exchange and development therapies in autistic children.Brain Dysfunct. 1991; 4: 335-347
- Auditory evoked responses and their modifications during conditioning paradigm in autistic children.J Autism Dev Disord. 1987; 17: 525-539
- An electrophysiological indication of auditory processing defects in autism.Psychiatry Res. 1980; 3: 107-114
- Les échelles d'efficiences intellectuelles.in: EDEI. Manuel et Matériel. Editions Scientifiques et Psychotechniques, New York1978
- Cluster analytic identification of autistic preschoolers.J Autism Dev Disord. 1988; 18: 475-492
- Implementation of a bioclinical database for research and treatment studies in childhood autism.Dev Brain Dysfunct. 1994; 7: 192-200
- Identification of behaviour profiles within a population of autistic children using multivariate statistical methods.Eur Child Adolesc Psychiatry. 1995; 4: 249-258
- Classification of autistic syndrome using behavioural and electrophysiological assessment.Dev Brain Dysfunct. 1997; 10: 28-39
- Play and languagein developmentally disorded preschoolers: A new approach to classification.J Am Acad Child Psychiatry. 1983; 22: 511-524
- Empirically derived subclassification of the autistic syndrome.J Autism Dev Disord. 1986; 16: 275-293
- Increasing the impact of cluster analysis research: The case of psychiatric classification.J Consult Clin Psychol. 1982; 50: 727-735
- EEG and neurophysiological studies of early infantile autism.Biol Psychiatry. 1975; 10: 385-397
- Asperger's syndrome and autism: Comparison of early history and outcome.Dev Med Child Neurol. 1989; 31: 709-720
- Echelle d'intelligence de Wechsler pour enfants.in: Forme révisée (WISC-R). Centre de Psychologie Appliquée, Paris1981
Article info
Publication history
Received in revised form:
September 25,
1996
Received:
April 8,
1996
Footnotes
This study was supported by INSERM Unit 316, INSERM Network No. 4R002B, INSERM-France TELECOM convention 1993, and Langlois Foundation.
Identification
Copyright
© 1997 Society of Biological Psychiatry. Published by Elsevier Inc.
