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Changes in regional cerebral blood flow (rCBF), associated with performance of an
auditory verbal supraspan memory task, were studied in eight remitted DSM-III-R schizophrenic
patients and eight pair-wise matched normal controls. Four positron emission tomography
(PET) scans, using the [15O]-H2O technique, were acquired: two while subjects fixated a cross hair and two while
performing a verbal free-recall supraspan memory task. Task performance showed typical
patterns of recency and primacy effects in both groups; however, patients performed
more poorly than controls on the primary (working) memory aspect of the task. Regions
showing rCBF changes overlapped in both groups and were similar to those seen in previous
studies of normals; however, patients had smaller increases in rCBF than controls
in frontal and superior temporal cortical regions bilaterally. Our results suggest
that remitted patients with schizophrenia demonstrate impairments of capacity-limited
information processing, which may be related to metabolic dysfunction within a distributed
network of brain structures, including the prefrontal and temporal cortical regions;
however, dysfunction limited to the frontal cortex cannot be ruled out by the results
of this experiment.
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Article Info
Publication History
Received in revised form:
March 26,
1996
Received:
May 11,
1995
Footnotes
This work was supported in part by MH49815-04 and by a NARSAD Young Investigator award to Cameron S. Carter M.D.
Identification
Copyright
© 1997 Society of Biological Psychiatry. Published by Elsevier Inc.
