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We tested the hypothesis that aberrant dopaminergic innervation in frontal and cingulate
cortices of schizophrenic patients might be revealed by examining dopamine D1 receptor
density in these brain regions. A quantitative autoradiographic assay with [3H]-SCH 23390 was performed with samples from schizophrenic patients, normal controls,
neuroleptic-treated controls, and suicides. There was a significant elevation in specific
binding of [3H]-SCH 23390 in the intermediate layer of the prefrontal cortex from neuroleptic-treated
controls (p = .05). Elevated [3H]-SCH 23390 binding in several layers from prefrontal and cingulate cortex was observed
in schizophrenic subjects, although these results did not reach statistical significance.
When data from subjects who had received neuroleptics (schizophrenics and neuroleptic
controls) were compared to subjects who had not received neuroleptics (normal controls
and suicides), there was a significant elevation in receptor density in both the prefrontal
(p = .05) and cingulate cortices (p = .03). These data suggest that elevated [3H]-SCH 23390 binding in human prefrontal and cingulate cortices may occur with chronic
neuroleptic treatment, although increased receptor density that may exist as a feature
of psychotic illnesses cannot be excluded.
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Article info
Publication history
Received in revised form:
February 19,
1996
Received:
September 11,
1995
Identification
Copyright
© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.