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Birth problems can lead to changes in brain morphology in the general population and
an increased prevalence of both birth problems and altered brain morphology are found
in patients with schizophrenia. The purpose of this study was to test the hypothesis
that these two findings are related. Birth history and the size of ventricular and
sulcal spaces from nine regions of the brain were assessed in 80 male subjects with
schizophrenia. No differences were found between patients with and those without a
history of birth problems for the size of any brain space; however, ventricular size
increased significantly with age in patients who had no birth complications but not
in patients with a history of birth problems. The size of cortical sulci increased
with age in patients with and those without a history of birth problems. These results
suggest that region-specific rates of change in size may identify clinically meaningful
patient subgroups.
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Article info
Publication history
Received in revised form:
December 27,
1995
Received:
August 22,
1994
Footnotes
Dr. W.G. Honer was supported by the Medical Research Council of Canada.
Identification
Copyright
© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.