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Original article| Volume 40, ISSUE 12, P1200-1208, December 15, 1996

Obstetric complications and age-related changes in brain morphology in schizophrenia

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      Birth problems can lead to changes in brain morphology in the general population and an increased prevalence of both birth problems and altered brain morphology are found in patients with schizophrenia. The purpose of this study was to test the hypothesis that these two findings are related. Birth history and the size of ventricular and sulcal spaces from nine regions of the brain were assessed in 80 male subjects with schizophrenia. No differences were found between patients with and those without a history of birth problems for the size of any brain space; however, ventricular size increased significantly with age in patients who had no birth complications but not in patients with a history of birth problems. The size of cortical sulci increased with age in patients with and those without a history of birth problems. These results suggest that region-specific rates of change in size may identify clinically meaningful patient subgroups.

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      References

        • Andreasen NC
        • Olsen SA
        • Dennert W
        • et al.
        Ventricular enlargement in schizophrenia: Relationship to positive and negative symptoms.
        Am J Psychiatry. 1982; 139: 297-302
        • Andreasen NC
        • Swayze VW
        • Flaum M
        • et al.
        Ventricular enlargement in schizophrenia evaluated with computed tomographic scanning: Effects of gender, age, and stage of illness.
        Arch Gen Psychiatry. 1990; 47: 1008-1015
        • Bilder RM
        • Wu H
        • Bogerts B
        • et al.
        Absence of regional hemispheric volume asymmetries in first-episode schizophrenia.
        Am J Psychiatry. 1994; 151: 1437-1447
        • Bogerts B
        The neuropathology of schizophrenia: Pathophysiological and neurodevelopmental implications.
        in: Mednick SA Cannon TD Fetal Neural Development and Adult Schizophrenia. Cambridge University Press, New York1991: 153-173
        • Bogerts B
        • Ashtari M
        • Degreef G
        • et al.
        Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia.
        Psychiatry Res Neuroimaging. 1990; 35: 1-13
        • Bornstein RA
        • Schwarzkopf SC
        • Olsen SC
        • et al.
        Third ventricle enlargement and neuropsychological deficit in schizophrenia.
        Biol Psychiatry. 1992; 31: 954-961
        • Boronow J
        • Pickar D
        • Ninan PT
        • et al.
        Atrophy limited to the third ventricle in chronic schizophrenic patients: Report of a controlled series.
        Arch Gen Psychiatry. 1985; 42: 266-270
        • Buckman TD
        • Kling AS
        • Eiduson S
        • et al.
        Glutathione peroxidase and CT scan abnormalities in schizophrenia.
        Biol Psychiatry. 1987; 22: 1349-1356
        • Cannon TD
        The possible neurodevelopmental significance of structural imaging findings in schizophrenia.
        in: Mednick SA Cannon TD Developmental Neuropathology of Schizophrenia. Plenum Press, Cambridge, England1991: 149-166
        • Cannon TD
        • Mednick SA
        • Parnas J
        Genetic and perinatal determinants of structural brain deficits in schizophrenia.
        Arch Gen Psychiatry. 1989; 46: 883-889
        • Degreef G
        • Ashtari M
        • Bogerts B
        • et al.
        Volumes of ventricular system subdivisions measured from magnetic resonance images in first-episode schizophrenic patients.
        Arch Gen Psychiatry. 1992; 49: 531-537
        • DeLisi LE
        • Goldin LR
        • Hamovit JR
        • et al.
        A family study of the association of increased ventricular size with schizophrenia.
        Arch Gen Psychiatry. 1986; 43: 148-156
        • DeLisi LE
        • Hoff AL
        • Schwartz JE
        • et al.
        Brain morphology in first-episode schizophreniclike psychotic patients: A quantitative magnetic resonance imaging study.
        Biol Psychiatry. 1991; 29: 159-175
        • DeLisi LE
        • Stritzke P
        • Riodan H
        • et al.
        The timing of brain morphological changes in schizophrenia and their relationship to clinical outcome.
        Biol Psychiatry. 1992; 31: 241-254
        • DeLisi LE
        • Hoff AL
        • Neale C
        • et al.
        Asymmetries of the superior temporal lobe in male and female first-episode schizophrenic patients: Measures of the planum temporale and superior temporal gyrus by MRI.
        Schizophr Res. 1994; 12: 19-28
        • DeLisi LE
        • Tew W
        • Xie S
        • et al.
        A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients: Preliminary findings.
        Biol Psychiatry. 1995; 38: 349-360
        • Farmer A
        • Jackson R
        • McGuffin P
        • et al.
        Cerebral ventricular enlargement in chronic schizophrenia: Consistencies and contradictions.
        Br J Psychiatry. 1987; 150: 324-330
        • Harvey I
        • Ron MA
        • DuBoulay G
        • et al.
        Reduction in cortical volume in schizophrenia on magnetic resonance imaging.
        Psychol Med. 1993; 23: 591-604
        • Hoff AL
        • Neal C
        • Kushner M
        • et al.
        Gender differences in corpus callosum size in first-episode schizophrenics.
        Biol Psychiatry. 1994; 35: 913-919
        • Honer WG
        • Bassett AS
        • Smith GN
        • et al.
        Temporal lobe abnormalities in multigenerational families with schizophrenia.
        Biol Psychiatry. 1994; 36: 737-743
        • Honer WG
        • Smith GN
        • Lapointe JS
        • et al.
        Regional cortical anatomy and clozapine response in refractory schizophrenia.
        Neuropsychopharmacology. 1995; 13: 85-87
        • Iacono WG
        • Smith GN
        • Moreau M
        • et al.
        Ventricular and sulcal size at the onset of psychosis.
        Am J Psychiatry. 1988; 145: 820-824
        • Kaplan MJ
        • Lazoff M
        • Kelly K
        • et al.
        Enlargement of the cerebral third ventricle in psychotic patients with delayed response to neuroleptics.
        Biol Psychiatry. 1990; 27: 205-214
        • Kemali D
        • Maj M
        • Galderisi S
        • et al.
        Ventricle-to-brain ratio in schizophrenia: A controlled follow-up study.
        Biol Psychiatry. 1989; 26: 756-759
        • Klausner JD
        • Sweeney JA
        • Deck MDF
        • et al.
        Clinical correlates of cerebral ventricular enlargement in schizophrenia: Further evidence for frontal lobe disease.
        J Nerv Ment Disease. 1992; 180: 407-412
        • Lewine RRJ
        • Hudgins P
        • Brown F
        • et al.
        Differences in qualitative brain morphology findings in schizophrenia, major depression, bipolar disorder and normal controls.
        Schizophr Res. 1995; 15: 253-259
        • Lewis SW
        • Murray RM
        • Owen MJ
        Obstetric complications in schizophrenia: Methodology and mechanisms.
        in: Schulz SC Tamminga CA Schizophrenia: Scientific Progress. Oxford University Press, New York1989: 56-68
        • Losonczy MF
        • Song IS
        • Mohs RC
        • et al.
        Correlates of lateral ventricular size in schizophrenia: I. Behavioral and treatment response measures.
        Am J Psychiatry. 1986; 143: 976-981
        • MacDonald HL
        • Best JJK
        The Scottish first episode study: IV. Computerized tomographic brain scans in patients and controls.
        Br J Psychiatry. 1989; 154: 492-498
        • Marsh L
        • Suddath RL
        • Higgins N
        • et al.
        Medial temporal lobe structures in schizophrenia: Relationship of size to duration of illness.
        Schizophr Res. 1994; 11: 225-238
        • McNeil TF
        Obstetric factors and perinatal injuries.
        in: Tsuang MT Simpson JR Handbook of Schizophrenia, Volume 3: Nosology, Epidemiology, and Genetics. Elsevier Science Publishers, New York1988: 319-344
        • McNeil TF
        • Sjöström K
        The McNeil-Sjöström OC Scale: A Comprehensive Scale for Measuring Obstetric Complications.
        Department of Psychiatry, Lund University, New York1994
        • Naber D
        • Albus M
        • Burke H
        • et al.
        Neuroleptic withdrawal in chronic schizophrenia: CT and endocrine variables relating to psychopathology.
        Psychiatry Res. 1985; 16: 207-219
        • Nyback H
        • Wiesel FA
        • Berrgren BM
        • et al.
        Computed tomography of the brain in patients with acute psychosis and in healthy volunteers.
        Acta Psychiatr Scand. 1982; 65: 403-414
        • O'Callaghan E
        • Buckley P
        • Redmond O
        • et al.
        Abnormalities in cerebral structure in schizophrenia on magnetic resonance imaging: Interpretation in relation to the neurodevelopmental hypothesis.
        J R Soc Med. 1992; 85: 227-231
        • Owen MJ
        • Lewis SW
        • Murray RM
        Obstetric complications and schizophrenia: A computed tomographic study.
        Psychol Med. 1988; 18: 331-339
        • Pearlson GD
        • Kim WS
        • Kubos KL
        • et al.
        Ventricle-brain ratio, computed tomographic density, and brain area in 50 schizophrenics.
        Arch Gen Psychiatry. 1989; 46: 690-697
        • Pfefferbaum A
        • Zipursky RB
        • Lim KO
        • et al.
        Computed tomographic evidence for generalized sulcal and ventricular enlargement in schizophrenia.
        Arch Gen Psychiatry. 1988; 45: 633-640
        • Rossi A
        • Stratta P
        • DeCataldo S
        • et al.
        Cortical and subcortical computed tomographic study in schizophrenia.
        J Psychiatr Res. 1988; 22: 99-105
        • Rossi A
        • Stratta P
        • Gallucci M
        • et al.
        Brain morphology in schizophrenia by magnetic resonance imaging.
        Acta Psychiatr Scand. 1988; 77: 741-745
        • Rubin P
        • Karle A
        • Moller-Madsen S
        • et al.
        Computerized tomography in newly diagnosed schizophrenia and schizophreniform disorder: A controlled blind study.
        Br J Psychiatry. 1993; 163: 604-612
        • Schaepfer TE
        • Harris GJ
        • Tien AY
        • et al.
        Decreased regional cortical gray matter volume in schizophrenia.
        Am J Psychiatry. 1994; 151: 842-848
        • Schulsinger F
        • Parnas J
        • Petersen ET
        • et al.
        Cerebral ventricular size in the offspring of schizophrenic mothers: A preliminary study.
        Arch Gen Psychiatry. 1984; 41: 602-606
        • Schulz SC
        • Koller MM
        • Kishore PR
        • et al.
        Ventricular enlargement in teenage patients with schizophrenia spectrum disorder.
        Am J Psychiatry. 1983; 140: 1592-1595
        • Schwartzkopf SB
        • Olsen SC
        • Coffman JA
        • et al.
        Third and lateral ventricular volumes in schizophrenia: Support for progressive enlargement of both structures.
        Psychopharmacol Bull. 1990; 26: 385-391
        • Shelton RC
        • Carson CN
        • Doran AR
        • et al.
        Cerebral structural pathology in schizophrenia: Evidence for a selective prefrontal cortical defect.
        Am J Psychiatry. 1988; 145: 154-163
        • Smith GN
        • MacEwan GW
        • Ancill RJ
        • et al.
        Diagnostic confusion in treatment-refractory psychotic patients.
        J Clin Psychiatry. 1992; 53: 197-200
        • Smith GN
        • Honer WG
        • Kopala L
        • et al.
        Obstetric complications and severity of illness in schizophrenia.
        Schizophr Res. 1994; 14: 113-120
        • Spitzer RL
        Psychiatric diagnosis: Are clinicians still necessary?.
        Comp Psychiatry. 1983; 24: 399-411
        • Stafford JL
        • Albert MS
        • Naeser MA
        • et al.
        Age-related differences in computed tomographic scan measurements.
        Arch Neurol. 1988; 45: 409-415
        • Turner SW
        • Toone BK
        • Brett-Jones JR
        Computerized scan changes in early schizophrenia.
        Psychol Med. 1986; 16: 219-225
        • Weinberger DR
        • DeLisi LE
        • Perman GP
        • et al.
        Computed tomography in schizophreniform disorder.
        Arch Gen Psychiatry. 1982; 39: 778-783
        • Wilms G
        • Vanongeval C
        • Baert AL
        • et al.
        Ventricular enlargement, clinical correlates and treatment outcome in chronic schizophrenia.
        Acta Psychiatr Scand. 1991; 85: 306-312
        • Woods BT
        • Yugelun-Todd D
        • Benes FM
        • et al.
        Progressive ventricular enlargement in schizophrenia: Comparison to bipolar affective disorder and correlation with clinical course.
        Biol Psychiatry. 1990; 27: 341-352