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Author Contributions
NK and JWL conceived the study. NK designed, performed experiments, and collected data. NK and JWL analyzed data. JWL assessed the quality of data. AWC facilitated collection of human cortical biopsies. BHK harvested human cortical biopsies. NK and AWC collected the human biopsies. NK and RLS performed section cutting, screening and multibeam imaging. YW aligned the human and mouse datasets. NK did manual segmentation in both human and mouse datasets. YM did automatic segmentation of the mouse dataset and computed the largest objects in the volume. NK and YM generated ground truth for automatic segmentation of mouse dataset. DW generated meshes of automatically segmented objects and assessed largest objects. YW wrote the MATLAB script for assessment of ECS and for statistical assessment of omegas. NK and JWL wrote the manuscript.
Disclosure
The authors declare no biomedical financial interests nor conflict of interest.
