Progress in understanding the molecular mechanisms underlying human psychiatric disease
has been hampered by a lack of models that can reflect the genetic states underlying
human cognitive disease and species-specific differences in brain development and
function. This is particularly true of sporadic forms of psychiatric disease, which
account for most cases; these cases are often associated with the cumulative contribution
of multiple common risk variants, each with small effects—a type of genetic structure
that is difficult or impossible to replicate in animal models. Human-derived induced
pluripotent stem cells are a revolutionary advance for the study of the contribution
of the broader genomic landscape to disease states, and the emergence of 3-dimensional
brain organoid models has opened a new window to investigate the cellular and molecular
underpinnings of human brain development and disease. In this special issue of Biological Psychiatry, leaders in this field offer their perspectives on the use of human organoid models
to understand psychiatric disease.
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References
- Development and application of brain region–specific organoids for investigating psychiatric disorders.Biol Psychiatry. 2023; 93: 594-605
- Present and future modeling of human psychiatric connectopathies with brain organoids.Biol Psychiatry. 2023; 93: 606-615
- Network and microcircuitry development in human brain organoids.Biol Psychiatry. 2023; 93: 590-593
- Transplantation strategies to enhance maturity and cellular complexity in brain organoids.Biol Psychiatry. 2023; 93: 616-621
- Stem cell–based organoid models of neurodevelopmental disorders.Biol Psychiatry. 2023; 93: 622-631
- What have organoids and assembloids taught us about the pathophysiology of neuropsychiatric disorders?.Biol Psychiatry. 2023; 93: 632-641
- Stem cell models for context-specific modeling in psychiatric disorders.Biol Psychiatry. 2023; 93: 642-650
Article info
Publication history
Accepted:
January 26,
2023
Received:
January 25,
2023
Identification
Copyright
© 2023 Society of Biological Psychiatry.
