Commentary| Volume 93, ISSUE 5, P384-385, March 01, 2023

Making Connections: Biological Mechanisms of Human Brain (Dys)connectivity

      Nervous systems are evidently complex networks on multiple spatial scales, from the microscopic scale of synaptically connected neuronal networks to the macroscopic scale of whole-brain connectomes. In biological psychiatry, various macroscopic network phenotypes are now routinely measured using a diverse group of magnetic resonance imaging (MRI) sequences and data analytic methods, supported by the growing fields of network neuroscience or connectomics. Just about every psychiatric, neurodevelopmental, and cognitive disorder has by now been associated with some evidence of atypical MRI network organization, or brain dysconnectivity.
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