In their correspondence, Hengartner and Plöderl (
1
) questioned the methods we used to analyze and interpret the data in our recent article
(
2
). We would like to comment on the points that they have raised.To read this article in full you will need to make a payment
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References
Hengartner MP, Plöderl M (in press): No clear evidence of reduced brain serotonin release capacity in patients with depression. Biol Psychiatry.
- Brain serotonin release is reduced in patients with depression: A [11C]CIMBI-36 PET study with a d-amphetamine challenge [published online Oct 29].Biol Psychiatry. 2022;
- Power failure: Why small sample size undermines the reliability of neuroscience.Nat Rev Neurosci. 2013; 14: 365-376
- Serotonin release measured in the human brain: A PET study with [11C]CIMBI-36 and d-amphetamine challenge.Neuropsychopharmacology. 2020; 45: 804-810
- Evidence-biased Antidepressant Prescription: Overmedicalisation, Flawed Research, and Conflicts of Interest.1st ed. Palgrave Macmillan, Cham, Switzerland2022
Article info
Publication history
Published online: February 08, 2023
Accepted:
November 30,
2022
Received:
November 30,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
See also associated correspondence: https://doi.org/10.1016/j.biopsych.2022.11.020.
Identification
Copyright
© 2022 Society of Biological Psychiatry.
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- No Clear Evidence of Reduced Brain Serotonin Release Capacity in Patients With DepressionBiological Psychiatry
- PreviewIn their recent article, Erritzoe et al. (1) reported that patients diagnosed with depression, compared with healthy control subjects, have a reduced serotonin release capacity (SRC). We want to point out several limitations of the statistical analyses and overinterpretation of study findings. For our reanalyses of the data, we digitized the data from Figure 1.
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