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Correspondence| Volume 93, ISSUE 12, e61, June 15, 2023

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No Clear Evidence of Reduced Brain Serotonin Release Capacity in Patients With Depression

  • Michael P. Hengartner
    Correspondence
    Address correspondence to Michael P. Hengartner, Ph.D.
    Affiliations
    Department of Applied Psychology, Zurich University of Applied Sciences, Zurich, Switzerland
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  • Martin Plöderl
    Affiliations
    Department of Inpatient Psychotherapy and Crisis Intervention, University Clinic for Psychiatry, Psychotherapy, and Psychosomatics, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria

    Department of Clinical Psychology, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria
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Published:February 09, 2023DOI:https://doi.org/10.1016/j.biopsych.2022.11.020
      In their recent article, Erritzoe et al. (
      • Erritzoe D.
      • Godlewska B.R.
      • Rizzo G.
      • Searle G.E.
      • Agnorelli C.
      • Lewis Y.
      • et al.
      Brain serotonin release is reduced in patients with depression: A [11C]Cimbi-36 positron emission tomography study with a d-amphetamine challenge.
      ) reported that patients diagnosed with depression, compared with healthy control subjects, have a reduced serotonin release capacity (SRC). We want to point out several limitations of the statistical analyses and overinterpretation of study findings. For our reanalyses of the data, we digitized the data from Figure 1.
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