In their recent article, Erritzoe et al. (
1
) reported that patients diagnosed with depression, compared with healthy control
subjects, have a reduced serotonin release capacity (SRC). We want to point out several
limitations of the statistical analyses and overinterpretation of study findings.
For our reanalyses of the data, we digitized the data from Figure 1.To read this article in full you will need to make a payment
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References
- Brain serotonin release is reduced in patients with depression: A [11C]Cimbi-36 positron emission tomography study with a d-amphetamine challenge.Biol Psychiatry. 2023; 93: 1089-1098
- Power failure: Why small sample size undermines the reliability of neuroscience.Nat Rev Neurosci. 2013; 14: 365-376
- Revised standards for statistical evidence.Proc Natl Acad Sci U S A. 2013; 110: 19313-19317
- Using Bayes to get the most out of non-significant results.Front Psychol. 2014; 5: 781
- An agenda for purely confirmatory research.Perspect Psychol Sci. 2012; 7: 632-638
- Variability in the analysis of a single neuroimaging dataset by many teams.Nature. 2020; 582: 84-88
- The role of exercise in the treatment of depression: Biological underpinnings and clinical outcomes [published online Oct 17].Mol Psychiatry. 2022;
Article info
Publication history
Published online: February 09, 2023
Accepted:
November 30,
2022
Received:
November 8,
2022
Footnotes
See also associated correspondence: https://doi.org/10.1016/j.biopsych.2022.11.021.
Identification
Copyright
© 2022 Society of Biological Psychiatry.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Brain Serotonin Release Is Reduced in Patients With Depression: A [11C]Cimbi-36 Positron Emission Tomography Study With a d-Amphetamine ChallengeBiological PsychiatryVol. 93Issue 12
- PreviewThe serotonin hypothesis of depression proposes that diminished serotonergic (5-HT) neurotransmission is causal in the pathophysiology of the disorder. Although the hypothesis is over 50 years old, there is no firm in vivo evidence for diminished 5-HT neurotransmission. We recently demonstrated that the 5-HT2A receptor agonist positron emission tomography (PET) radioligand [11C]Cimbi-36 is sensitive to increases in extracellular 5-HT induced by an acute d-amphetamine challenge. Here we applied [11C]Cimbi-36 PET to compare brain 5-HT release capacity in patients experiencing a major depressive episode (MDE) to that of healthy control subjects (HCs) without depression.
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- Reply to: No Clear Evidence of Reduced Brain Serotonin Release Capacity in Patients With DepressionBiological PsychiatryVol. 93Issue 12
