In their recent article, Erritzoe et al. (
1) reported that patients diagnosed with depression, compared with healthy control subjects, have a reduced serotonin release capacity (SRC). We want to point out several limitations of the statistical analyses and overinterpretation of study findings. For our reanalyses of the data, we digitized the data from Figure 1.
- Erritzoe D.
- Godlewska B.R.
- Rizzo G.
- Searle G.E.
- Agnorelli C.
- Lewis Y.
- et al.
Brain serotonin release is reduced in patients with depression: A [11C]Cimbi-36 positron emission tomography study with a d-amphetamine challenge.
Biol Psychiatry. 2023; 93: 1089-1098
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- Brain serotonin release is reduced in patients with depression: A [11C]Cimbi-36 positron emission tomography study with a d-amphetamine challenge.Biol Psychiatry. 2023; 93: 1089-1098
- Power failure: Why small sample size undermines the reliability of neuroscience.Nat Rev Neurosci. 2013; 14: 365-376
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Published online: February 09, 2023
Accepted: November 30, 2022
Received: November 8, 2022
See also associated correspondence: https://doi.org/10.1016/j.biopsych.2022.11.021.
© 2022 Society of Biological Psychiatry.
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- Brain Serotonin Release Is Reduced in Patients With Depression: A [11C]Cimbi-36 Positron Emission Tomography Study With a d-Amphetamine ChallengeBiological PsychiatryVol. 93Issue 12
- PreviewThe serotonin hypothesis of depression proposes that diminished serotonergic (5-HT) neurotransmission is causal in the pathophysiology of the disorder. Although the hypothesis is over 50 years old, there is no firm in vivo evidence for diminished 5-HT neurotransmission. We recently demonstrated that the 5-HT2A receptor agonist positron emission tomography (PET) radioligand [11C]Cimbi-36 is sensitive to increases in extracellular 5-HT induced by an acute d-amphetamine challenge. Here we applied [11C]Cimbi-36 PET to compare brain 5-HT release capacity in patients experiencing a major depressive episode (MDE) to that of healthy control subjects (HCs) without depression.
- Reply to: No Clear Evidence of Reduced Brain Serotonin Release Capacity in Patients With DepressionBiological PsychiatryVol. 93Issue 12