Advertisement

A Methylome-Based Signature of Stress: Association With Accelerated Epigenetic Aging and Alcohol Use

  • Katharina Domschke
    Correspondence
    Address correspondence to Katharina Domschke, Ph.D., M.D., M.A.
    Affiliations
    Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
    Search for articles by this author
      Epigenetic mechanisms have been suggested to be located at the interface between the genetic and the environmental levels. In animal as well as human studies, epigenetic mechanisms have been proposed to dynamically adjust to environmental challenges such as stress in an adaptive or maladaptive way [cf. (
      • Schiele M.A.
      • Gottschalk M.G.
      • Domschke K.
      The applied implications of epigenetics in anxiety, affective and stress-related disorders – A review and synthesis on psychosocial stress, psychotherapy and prevention.
      ,
      • Gottschalk M.G.
      • Domschke K.
      • Schiele M.A.
      Epigenetics underlying susceptibility and resilience relating to daily life stress, work stress, and socioeconomic status.
      )] and thus to contribute to resilience or risk, respectively, toward stress-related disorders as well as substance abuse disorders, which are inherently tied to stress-related disorders.
      SEE CORRESPONDING ARTICLE ON PAGE 331
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Schiele M.A.
        • Gottschalk M.G.
        • Domschke K.
        The applied implications of epigenetics in anxiety, affective and stress-related disorders – A review and synthesis on psychosocial stress, psychotherapy and prevention.
        Clin Psychol Rev. 2020; 77101830
        • Gottschalk M.G.
        • Domschke K.
        • Schiele M.A.
        Epigenetics underlying susceptibility and resilience relating to daily life stress, work stress, and socioeconomic status.
        Front Psychiatry. 2020; 11: 163
        • Jung J.
        • McCartney D.L.
        • Wagner J.
        • Yoo J.
        • Bell A.S.
        • Mavromatis L.A.
        • et al.
        Additive effects of stress and alcohol exposure on accelerated epigenetic aging in alcohol use disorder.
        Biol Psychiatry. 2023; 93: 331-341
        • Zannas A.S.
        • Arloth J.
        • Carrillo-Roa T.
        • Iurato S.
        • Röh S.
        • Ressler K.J.
        • et al.
        Lifetime stress accelerates epigenetic aging in an urban, African American cohort: Relevance of glucocorticoid signaling.
        Genome Biol. 2015; 16: 266
        • Boks M.P.
        • van Mierlo H.C.
        • Rutten B.P.
        • Radstake T.R.
        • De Witte L.
        • Geuze E.
        • et al.
        Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder.
        Psychoneuroendocrinology. 2015; 51: 506-512
        • Domschke K.
        Prevention in psychiatry: A role for epigenetics?.
        World Psychiatry. 2021; 20: 227-228
        • Zannas A.S.
        • Chrousos G.P.
        Epigenetic programming by stress and glucocorticoids along the human lifespan.
        Mol Psychiatry. 2017; 22: 640-646
      1. Ell MA, Schiele MA, Iovino N, Domschke K (in press): Epigenetics of fear, anxiety and stress – focus on histone modifications. Curr Neuropharmacol.

        • Brody G.H.
        • Yu T.
        • Chen E.
        • Beach S.R.
        • Miller G.E.
        Family-centered prevention ameliorates the longitudinal association between risky family processes and epigenetic aging.
        J Child Psychol Psychiatry. 2016; 57: 566-574
        • Beach S.R.
        • Lei M.K.
        • Brody G.H.
        • Yu T.
        • Philibert R.A.
        Nonsupportive parenting affects telomere length in young adulthood among African Americans: Mediation through substance use.
        J Fam Psychol. 2014; 28: 967-972

      Linked Article