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Accepted: October 20, 2022
Received: October 18, 2022
© 2022 Society of Biological Psychiatry.
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- Leveraging Machine Learning for Gaining Neurobiological and Nosological Insights in Psychiatric ResearchBiological PsychiatryVol. 93Issue 1
- PreviewMuch attention is currently devoted to developing diagnostic classifiers for mental disorders. Complementing these efforts, we highlight the potential of machine learning to gain biological insights into the psychopathology and nosology of mental disorders. Studies to this end have mainly used brain imaging data, which can be obtained noninvasively from large cohorts and have repeatedly been argued to reveal potentially intermediate phenotypes. This may become particularly relevant in light of recent efforts to identify magnetic resonance imaging–derived biomarkers that yield insight into pathophysiological processes as well as to refine the taxonomy of mental illness.