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Article info
Publication history
Accepted:
October 18,
2022
Received:
October 18,
2022
Identification
Copyright
Published by Elsevier Inc on behalf of Society of Biological Psychiatry.
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- Cellular Genome-wide Association Study Identifies Common Genetic Variation Influencing Lithium-Induced Neural Progenitor ProliferationBiological PsychiatryVol. 93Issue 1
- PreviewBipolar disorder is a highly heritable neuropsychiatric condition affecting more than 1% of the human population. Lithium salts are commonly prescribed as a mood stabilizer for individuals with bipolar disorder. Lithium is clinically effective in approximately half of treated individuals, and their genetic backgrounds are known to influence treatment outcomes. While the mechanism of lithium’s therapeutic action is unclear, it stimulates adult neural progenitor cell proliferation, similar to some antidepressant drugs.
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