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Dr. Paus reports no biomedical financial interests or potential conflicts of interest.
1 Function-to-form refers here to processes underpinned by neuronal plasticity.
2 Term introduced in 1891 by a German anatomist Waldeyer 1. Jones EG (1994): The Neuron Doctrine 1891. J Hist Neurosci. 3:3-20.
3 In his histological work, Cajal used a silver staining method (and its modification) that was discovered, in 1873, by Camilo Golgi. Golgi called it la reazione nera (the black reaction).
4 Synapses are found between axon and either dendrites (99.4%), axon initial segment (0.197%) or soma (0.393%). 3. Shapson-Coe A (2022): A connectomic study of a petascale fragment of human cerebral cortex. bioRxiv.
5 Some of the consistencies with previous findings include: % of interneurons (29% of all neurons), % of oligodendrocytes (62% of all glial cells) and % of astrocytes (16.9%). Some of the discrepancies include a lower-than-expected % of pyramidal cells (54.7% of all neurons), and a higher-than-expected % of microglia (20% of all glial cells). But the proportion of excitatory (109.2 million) and inhibitory (40.6 million) synapses corresponds to the previously reported numbers of pyramidal cells (75%) and interneurons (25%). The glia-to-neuron ratio of 2.0 is somewhat higher than the ratios reported previously.
6 For comparison, Braitenberg reported the following relative volumes in the mouse cerebral cortex: 29.3% of unmyelinated axons, 30.2% of dendrites and 19.5% of glial cells 19. Braitenberg V (2001): Brain size and number of neurons: an exercise in synthetic neuroanatomy. Journal of computational neuroscience. 10:71-77..