Abstract:
Background
Methods
Results
Conclusions
Keywords
Introduction:
Methods:
Design
Extraction of region coordinates across subjects
Region | MNI coordinates | Network | ||
---|---|---|---|---|
x | y | z | ||
PCC | 0 | -73 | 38 | DMN |
mPFC | 0 | 53 | 32 | DMN |
lAG | -54 | -61 | 29 | DMN |
rAG | 57 | -58 | 20 | DMN |
dACC | 0 | 17 | 41 | SN |
lAI | -48 | 14 | -7 | SN |
rAI | 48 | 14 | -7 | SN |
lFEF | -30 | -10 | 68 | DAN |
rFEF | 30 | -7 | 68 | DAN |
lIPS/SPL | -42 | -43 | 62 | DAN |
rIPS/SPL | 39 | -40 | 65 | DAN |
Specification and inversion of DCM
Second level analysis using Parametric Empirical Bayes
Network level effective connectivity and hierarchical organization
Results
Acute Effects
Between networks changes in effective connectivity


Lasting Effects
Between networks changes in effective connectivity.
Behavioural Associations to Ego Dissolution
Discussion
Acknowledgments
Supplementary Material
References
- Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis.Neuropsychopharmacology. 1997; 16: 357-372
- Advances and pathophysiological models of hallucinogenic drug actions in humans: a preamble to schizophrenia research.Pharmacopsychiatry. 1998; 31: 92-103
- Phenomenology, Structure, and Dynamic of Psychedelic States.Curr Top Behav Neurosci. 2018; 36: 221-256
Johnson M, Richards W, Griffiths R (2008): Human hallucinogen research: guidelines for safety. London, England, pp 603-620.
- How do psychedelics work?.Current Opinion in Psychiatry. 2018; 1
- Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression.Frontiers in Pharmacology. 2018; 8: 974
- The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects.ACS Pharmacology & Translational Science. 2020;
Stoliker D, Egan G, Friston K, Razi A (2021): Neural Mechanisms and Psychology of Psychedelic Ego Dissolution. PsyArXiv.
- The standardized psychometric assessment of altered states of consciousness (ASCs) in humans.Pharmacopsychiatry. 1998; 31: 80-84
- Psychometric evaluation of the altered states of consciousness rating scale (OAV).PloS one. 2010; 5 (e12412-e12412)
- Classic Psychedelic drugs: update of biological mechanism.Pharmacopsychiatry. 2021; (in press)
- Finding the self by losing the self: Neural correlates of ego-dissolution under psilocybin.Human Brain Mapping. 2015; 36: 3137-3153
Grof S (1980): LSD Psychotherapy. Alameda, CA: Hunter House Publishers.
- Ego-Dissolution and Psychedelics: Validation of the Ego-Dissolution Inventory (EDI).Frontiers in Human Neuroscience. 2016; 10
- Altered network hub connectivity after acute LSD administration.Neuroimage Clin. 2018; 18: 694-701
- Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor.Elife. 2018; 7e35082
- The brain's default mode network.Annual review of neuroscience. 2015; 38: 433-447
- Functional and effective connectivity: a review.Brain Connect. 2011; 1: 13-36
- Default-Mode Activity during a Passive Sensory Task: Uncoupled from Deactivation but Impacting Activation.Journal of cognitive neuroscience. 2004; 16: 1484-1492
- The human brain is intrinsically organized into dynamic, anticorrelated functional networks.Proceedings of the National Academy of Sciences of the United States of America. 2005; 102: 9673
- A default mode of brain function.Proc Natl Acad Sci U S A. 2001; 98: 676-682
- The default network and self-generated thought: component processes, dynamic control, and clinical relevance.Annals of the New York Academy of Sciences. 2014; 1316: 29-52
- Control of Goal-Directed and Stimulus-Driven Attention in the Brain.Nature reviews Neuroscience. 2002; 3: 201-215
- Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.Nature Reviews Neuroscience. 2007; 8: 700-711
- Interactions between the salience and default-mode networks are disrupted in cocaine addiction.The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015; 35: 8081-8090
- Dissociable intrinsic connectivity networks for salience processing and executive control.J Neurosci. 2007; 27: 2349-2356
- Are the neural correlates of stopping and not going identical? Quantitative meta-analysis of two response inhibition tasks.NeuroImage. 2011; 56: 1655-1665
- Bayesian prediction and evaluation in the anterior cingulate cortex.J Neurosci. 2013; 33: 2039-2047
- Large-scale brain networks and psychopathology: a unifying triple network model.Trends Cogn Sci. 2011; 15: 483-506
- The Statistical Neuroanatomy of Frontal Networks in the Macaque.PLOS Computational Biology. 2008; 4e1000050
- Cingulate cortex of the rhesus monkey: II. Cortical afferents.Journal of Comparative Neurology. 1987; 262: 271-289
Menon V (2015): Salience Network. Elsevier.
- Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex.Molecular Brain. 2020; 13: 99
- Saliency, switching, attention and control: a network model of insula function.Brain Struct Funct. 2010; 214: 655-667
- A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks.Proceedings of the National Academy of Sciences. 2008; 10512569
- Salience, relevance, and firing: a priority map for target selection.Trends Cogn Sci. 2006; 10: 382-390
- Neural Integration of Top-Down Spatial and Feature-Based Information in Visual Search.J Neurosci. 2008; 28: 6141
- Functional and structural architecture of the human dorsal frontoparietal attention network.Proceedings of the National Academy of Sciences. 2013; 11015806
- Salience and Default Mode Network Coupling Predicts Cognition in Aging and Parkinson's Disease.J Int Neuropsychol Soc. 2016; 22: 205-215
- Interactions of the Salience Network and Its Subsystems with the Default-Mode and the Central-Executive Networks in Normal Aging and Mild Cognitive Impairment.Brain connectivity. 2017; 7: 401-412
- Salience network integrity predicts default mode network function after traumatic brain injury.Proc Natl Acad Sci U S A. 2012; 109: 4690-4695
- Aberrant dependence of default mode/central executive network interactions on anterior insular salience network activity in schizophrenia.Schizophr Bull. 2014; 40: 428-437
- Aberrant Coupling Within and Across the Default Mode, Task-Positive, and Salience Network in Subjects at Risk for Psychosis.Schizophrenia bulletin. 2013; 40
- Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction.J Psychiatry Neurosci. 2012; 37: 17-27
- Resting-State Neuroimaging Studies: A New Way of Identifying Differences and Similarities among the Anxiety Disorders?.The Canadian Journal of Psychiatry. 2014; 59: 294-300
- Full-body illusions and minimal phenomenal selfhood.Trends Cogn Sci. 2009; 13: 7-13
Legrand D, Ruby P (2009): What is self-specific? Theoretical investigation and critical review of neuroimaging results. American Psychological Association, pp 252-282.
- Increased Salience Network Activity in Patients With Insomnia Complaints in Major Depressive Disorder.Frontiers in psychiatry. 2018; 9 (93-93)
- Mindfulness is associated with intrinsic functional connectivity between default mode and salience networks.Frontiers in Human Neuroscience. 2015; 9: 461
- Default Mode Network, Meditation, and Age-Associated Brain Changes: What Can We Learn from the Impact of Mental Training on Well-Being as a Psychotherapeutic Approach?.Neural Plasticity. 2019. 2019; : 1-15
- Psychedelics and the science of self-experience.Br J Psychiatry. 2017; 210: 177-179
- Neuropharmacological modulation of the aberrant bodily self through psychedelics.Neurosci Biobehav Rev. 2020; 108: 526-541
Metzinger T (2003): Being no one: The self-model theory of subjectivity. Cambridge, MA, US: MIT Press.
- Looking for the Self: Phenomenology, Neurophysiology and Philosophical Significance of Drug-induced Ego Dissolution.Frontiers in Human Neuroscience. 2017; 11
- Default mode network can support the level of detail in experience during active task states.Proceedings of the National Academy of Sciences. 2018; 115: 9318-9323
- Dark control: The default mode network as a reinforcement learning agent.Human brain mapping. 2020; 41: 3318-3341
- Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders.Nature Reviews Neuroscience. 2020; 21: 611-624
- The default-mode, ego-functions and free-energy: a neurobiological account of Freudian ideas.Brain. 2010; 133: 1265-1283
- Psychoanalysis and Neuroscience: The Bridge Between Mind and Brain.Frontiers in Psychology. 2019; 10
- Changes in default-mode network activity and functional connectivity as an indicator of psychedelic-assisted psychotherapy effectiveness.Neuropsychiatria I Neuropsychologia. 2018; 13: 91-97
- Mind wandering and attention during focused meditation: a fine-grained temporal analysis of fluctuating cognitive states.Neuroimage. 2012; 59: 750-760
- Meditation experience is associated with differences in default mode network activity and connectivity.Proceedings of the National Academy of Sciences. 2011; 108: 20254-20259
Batchelor S (2008): Buddhism without beliefs : a contemporary guide to awakening. London: Bloomsbury.
- Psychedelics, Meditation, and Self-Consciousness.Frontiers in Psychology. 2018; 9
- A review of the clinical effects of psychotomimetic agents.Ann N Y Acad Sci. 1957; 66: 418-434
- Unifying Theories of Psychedelic Drug Effects.Frontiers in Pharmacology. 2018; 9
- The Current Status of Psychedelics in Psychiatry.JAMA psychiatry. 2020;
- Psilocybin with psychological support for treatment-resistant depression: six-month follow-up.Psychopharmacology. 2018; 235: 399-408
- Meditation programs for psychological stress and well-being: a systematic review and meta-analysis.JAMA Intern Med. 2014; 174: 357-368
- Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial.Journal of Psychopharmacology. 2016; 30: 1165-1180
- Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial.Journal of Psychopharmacology. 2016; 30: 1181-1197
- Self-centeredness and selflessness: happiness correlates and mediating psychological processes.PeerJ. 2017; 5e3306
- Influence of meditation on anti-correlated networks in the brain.Frontiers in Human Neuroscience. 2012; 5: 183
- Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis.Schizophrenia Bulletin. 2012; 39: 1343-1351
- The psychedelic state induced by ayahuasca modulates the activity and connectivity of the default mode network.PLoS One. 2015; 10e0118143
- Dynamic causal modelling.Neuroimage. 2003; 19: 1273-1302
- A DCM for resting state fMRI.NeuroImage. 2014; 94: 396-407
- Effective connectivity changes in LSD-induced altered states of consciousness in humans.Proceedings of the National Academy of Sciences. 2019; 116: 2743-2748
- The Hierarchical Organization of the Default, Dorsal Attention and Salience Networks in Adolescents and Young Adults.Cereb Cortex. 2018; 28: 726-737
- Self-referential processing in our brain--a meta-analysis of imaging studies on the self.Neuroimage. 2006; 31: 440-457
- All roads lead to the default-mode network-global source of DMN abnormalities in major depressive disorder.Neuropsychopharmacology. 2020; 45: 2058-2069
- A method for making group inferences from functional MRI data using independent component analysis.Hum Brain Mapp. 2001; 14: 140-151
- Toward discovery science of human brain function.Proceedings of the National Academy of Sciences. 2010; 107: 4734
- Decoding subject-driven cognitive states with whole-brain connectivity patterns.Cereb Cortex. 2012; 22: 158-165
- Extrinsic and Intrinsic Brain Network Connectivity Maintains Cognition across the Lifespan Despite Accelerated Decay of Regional Brain Activation.J Neurosci. 2016; 36: 3115-3126
- Functional-anatomic fractionation of the brain's default network.Neuron. 2010; 65: 550-562
- Interactions between the default network and dorsal attention network vary across default subsystems, time, and cognitive states.Neuroimage. 2017; 147: 632-649
- Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis.Hum Brain Mapp. 2005; 26: 15-29
- The global signal and observed anticorrelated resting state brain networks.J Neurophysiol. 2009; 101: 3270-3283
- Functional connectivity of default mode network components: correlation, anticorrelation, and causality.Hum Brain Mapp. 2009; 30: 625-637
- Dissociated patterns of anti-correlations with dorsal and ventral default-mode networks at rest.Human Brain Mapping. 2017; 38: 2454-2465
- Construct validation of a DCM for resting state fMRI.NeuroImage. 2015; 106: 1-14
- Bayesian model reduction and empirical Bayes for group (DCM) studies.Neuroimage. 2016; 128: 413-431
- Mapping the Hierarchical Layout of the Structural Network of the Macaque Prefrontal Cortex.Cerebral Cortex. 2012; 24: 1178-1194
- The hierarchical organization of the lateral prefrontal cortex.Elife. 2016; 5
- Intrinsic functional connectivity predicts individual differences in distractibility.Neuropsychologia. 2016; 86: 176-182
- Age differences in the neural correlates of distraction regulation: A network interaction approach.NeuroImage. 2016; 139
- Serotonergic Hallucinogen-Induced Visual Perceptual Alterations.Curr Top Behav Neurosci. 2018; 36: 257-282
- Neural correlates of the LSD experience revealed by multimodal neuroimaging.Proceedings of the National Academy of Sciences of the United States of America. 2016; 113: 4853-4858
- Broadband Cortical Desynchronization Underlies the Human Psychedelic State.J Neurosci. 2013; 33: 15171-15183
- Whatever next? Predictive brains, situated agents, and the future of cognitive science.Behav Brain Sci. 2013; 36: 181-204
- The free-energy principle: a unified brain theory?.Nature Reviews Neuroscience. 2010; 11: 127
- Homological scaffolds of brain functional networks.Journal of The Royal Society Interface. 2014; 1120140873
- Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution.Curr Biol. 2016; 26: 1043-1050
- Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex.Neuroimage. 2022; 256119220
- Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison.Schizophrenia Bulletin. 2020;
- Triple Network Model Dynamically Revisited: Lower Salience Network State Switching in Pre-psychosis.Frontiers in Physiology. 2020; 11
- The Triple Network Model, Insight, and Large-Scale Brain Organization in Autism.Biological psychiatry. 2018; 84: 236-238
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