The discovery of anti–NMDA receptor encephalitis in 2007 provided enormous boosts
to immunological research in neurology and psychiatry. Anti–NMDA receptor encephalitis
is associated with severe neurological and a plethora of psychiatric symptoms, including
psychotic and affective phenomena (
1
,
2
). To date, several more well-characterized neuronal autoantibodies have been described
(
1
,
2
). According to current international consensus criteria, a diagnosis of possible
autoimmune encephalitis (AE) should be considered in the presence of a subacute neuropsychiatric
syndrome (with severe working memory deficits, an altered mental state, or psychiatric
symptoms) in combination with at least one further organic sign, such as inflammatory
cerebrospinal fluid (CSF) changes with an increased white blood cell (WBC) count,
suspicious magnetic resonance imaging (MRI) changes, epileptic seizures, or focal
neurological signs (
2
).
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References
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- Neuroinflammatory biomarkers in cerebrospinal fluid from 106 patients with recent-onset depression compared with 106 individually matched healthy control subjects.Biol Psychiatry. 2022; 92: 563-572
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Article Info
Publication History
Accepted:
June 27,
2022
Received:
June 26,
2022
Identification
Copyright
© 2022 Society of Biological Psychiatry.
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- Neuroinflammatory Biomarkers in Cerebrospinal Fluid From 106 Patients With Recent-Onset Depression Compared With 106 Individually Matched Healthy Control SubjectsBiological PsychiatryVol. 92Issue 7Open Access
