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Epigenetic Reprogramming Within the Nucleus Accumbens Sustains Lasting Detrimental Effects of Prenatal Cannabis Exposure on Motivation

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      References

        • Badowski S.
        • Smith G.
        Cannabis use during pregnancy and postpartum.
        Can Fam Physician. 2020; 66: 98-103
        • Harkany T.
        • Cinquina V.
        Physiological rules of endocannabinoid action during fetal and neonatal brain development.
        Cannabis Cannabinoid Res. 2021; 6: 381-388
        • Biegon A.
        • Kerman I.A.
        Autoradiographic study of pre- and postnatal distribution of cannabinoid receptors in human brain.
        Neuroimage. 2001; 14: 1463-1468
        • Wanner N.M.
        • Colwell M.L.
        • Faulk C.
        The epigenetic legacy of illicit drugs: Developmental exposures and late-life phenotypes.
        Environ Epigenet. 2019; 5: dvz022
        • Ellis R.J.
        • Bara A.
        • Vargas C.A.
        • Frick A.L.
        • Loh E.
        • Landry J.
        • et al.
        Prenatal Δ9-tetrahydrocannabinol exposure in males leads to motivational disturbances related to striatal epigenetic dysregulation.
        Biol Psychiatry. 2022; 92: 127-138
        • Bilbao A.
        • Neuhofer D.
        • Sepers M.
        • Wei S.-P.
        • Eisenhardt M.
        • Hertle S.
        • et al.
        Endocannabinoid LTD in accumbal D1 neurons mediates reward-seeking behavior.
        iScience. 2020; 23: 100951
        • Di Bartolomeo M.
        • Stark T.
        • Maurel O.M.
        • Iannotti F.A.
        • Kuchar M.
        • Ruda-Kucerova J.
        • et al.
        Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in schizophrenia: Analyses in patients and in perinatal Δ9-tetrahydrocannabinol-exposed rats.
        Pharmacol Res. 2021; 164: 105357
        • Traccis F.
        • Serra V.
        • Sagheddu C.
        • Congiu M.
        • Saba P.
        • Giua G.
        • et al.
        Prenatal THC does not affect female mesolimbic dopaminergic system in preadolescent rats.
        Int J Mol Sci. 2021; 22: 1666
        • Chandra S.
        • Radwan M.M.
        • Majumdar C.G.
        • Church J.C.
        • Freeman T.P.
        • ElSohly M.A.
        New trends in cannabis potency in USA and Europe during the last decade (2008-2017).
        Eur Arch Psychiatry Clin Neurosci. 2019; 269: 5-15
        • Richardson K.A.
        • Hester A.K.
        • McLemore G.L.
        Prenatal cannabis exposure – The “first hit” to the endocannabinoid system.
        Neurotoxicol Teratol. 2016; 58: 5-14

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