The High Road to Inhibiting Fear Memories

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        • Ojala K.E.
        • Staib M.
        • Gerster S.
        • Ruff C.C.
        • Bach D.R.
        Inhibiting human aversive memory by transcranial theta-burst stimulation to the primary sensory cortex.
        Biol Psychiatry. 2022; 92: 149-157
        • LeDoux J.E.
        Emotion, memory and the brain.
        Sci Am. 1994; 270: 50-57
        • Sacco T.
        • Sacchetti B.
        Role of secondary sensory cortices.
        Science. 2010; 329: 649-657
        • Cambiaghi M.
        • Grosso A.
        • Likhtik E.
        • Mazziotti R.
        • Concina G.
        • Renna A.
        • et al.
        Higher-order sensory cortex drives basolateral amygdala activity during the recall of remote, but not recently learned fearful memories.
        J Neurosci. 2016; 36: 1647-1659
        • Yang Y.
        • Liu D.Q.
        • Huang W.
        • Deng J.
        • Sun Y.
        • Zuo Y.
        • Poo M.M.
        Selective synaptic remodeling of amygdalocortical connections associated with fear memory.
        Nat Neurosci. 2016; 19: 1348-1355
        • Grosso A.
        • Cambiaghi M.
        • Milano L.
        • Renna A.
        • Sacco T.
        • Sacchetti B.
        Region- and layer-specific activation of the higher order auditory cortex Te2 after remote retrieval of fear or appetitive memories.
        Cereb Cortex. 2017; 27: 3140-3151
        • Li Z.
        • Yan A.
        • Guo K.
        • Li W.
        Fear-related signals in the primary visual cortex.
        Curr Biol. 2019; 29: 4078-4083.e2
        • Wood K.C.
        • Angeloni C.F.
        • Oxman K.
        • Clopath C.
        • Geffen M.N.
        Neuronal activity in sensory cortex predicts the specificity of learning in mice.
        Nat Commun. 2022; 13: 1167
        • Aschauer D.F.
        • Eppler J.B.
        • Ewig L.
        • Chambers A.R.
        • Pokorny C.
        • Kaschube M.
        • Rumpel S.
        Learning-induced biases in the ongoing dynamics of sensory representations predict stimulus generalization.
        Cell Rep. 2022; 38: 110340
        • Domínguez-Borràs J.
        • Rieger S.W.
        • Corradi-Dell’Acqua C.
        • Neveu R.
        • Vuilleumier P.
        Fear spreading across senses: Visual emotional events alter cortical responses to touch, audition, and vision.
        Cereb Cortex. 2017; 27: 68-82

      Linked Article

      • Inhibiting Human Aversive Memory by Transcranial Theta-Burst Stimulation to the Primary Sensory Cortex
        Biological PsychiatryVol. 92Issue 2
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          Predicting adverse events from past experience is fundamental for many biological organisms. However, some individuals suffer from maladaptive memories that impair behavioral control and well-being, e.g., after psychological trauma. Inhibiting the formation and maintenance of such memories would have high clinical relevance. Previous preclinical research has focused on systemically administered pharmacological interventions, which cannot be targeted to specific neural circuits in humans. Here, we investigated the potential of noninvasive neural stimulation on the human sensory cortex in inhibiting aversive memory in a laboratory threat conditioning model.
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