Advertisement
Biological Psychiatry
Advanced SearchSave search
Early Career Investigator Commentary| Volume 92, ISSUE 1, e1-e3, July 01, 2022

Emerging Neuropsychiatric Symptoms May Represent an Early Manifestation of Preclinical Alzheimer’s Disease

DOI:https://doi.org/10.1016/j.biopsych.2022.04.013
Emerging Neuropsychiatric Symptoms May Represent an Early Manifestation of Preclinical Alzheimer’s Disease
Previous ArticleSex and the Brain: Novel ADNP Syndrome Mice Are Protected by NAP
Next ArticleBAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance
      Neuropsychiatric symptoms (NPSs) of dementia are behavioral and psychiatric symptoms of dementia that include disturbances of mood, perception, and behavior (
      • Lyketsos C.G.
      • Carrillo M.C.
      • Ryan J.M.
      • Khachaturian A.S.
      • Trzepacz P.
      • Amatniek J.
      • et al.
      Neuropsychiatric symptoms in Alzheimer’s disease.
      Alzheimers Dement. 2011; 7: 532-539
      ). NPSs are common in individuals with dementia and are associated with increased functional impairment and caregiver burden, a lower satisfaction with life, a higher burden of neuropathic markers of dementia, and an accelerated speed of disease progression (
      • Ismail Z.
      • Smith E.E.
      • Geda Y.
      • Sultzer D.
      • Brodaty H.
      • Smith G.
      • et al.
      Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment.
      Alzheimers Dement. 2016; 12: 195-202
      ). NPSs can appear relatively early, even before a diagnosis of dementia, may progress in parallel with cognitive decline, and may be early behavioral markers of Alzheimer's disease (AD) pathology (
      • Donovan N.J.
      • Locascio J.J.
      • Marshall G.A.
      • Gatchel J.
      • Hanseeuw B.J.
      • Rentz D.M.
      • et al.
      Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults.
      Am J Psychiatry. 2018; 175: 530-537
      ,
      • Johansson M.
      • Stomrud E.
      • Lindberg O.
      • Westman E.
      • Johansson P.M.
      • van Westen D.
      • et al.
      Apathy and anxiety are early markers of Alzheimer’s disease.
      Neurobiol Aging. 2020; 85: 74-82
      ).
      SEE CORRESPONDING ARTICLE ON PAGE 34
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Lyketsos C.G.
        • Carrillo M.C.
        • Ryan J.M.
        • Khachaturian A.S.
        • Trzepacz P.
        • Amatniek J.
        • et al.
        Neuropsychiatric symptoms in Alzheimer’s disease.
        Alzheimers Dement. 2011; 7: 532-539
        View in Article
        • Ismail Z.
        • Smith E.E.
        • Geda Y.
        • Sultzer D.
        • Brodaty H.
        • Smith G.
        • et al.
        Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment.
        Alzheimers Dement. 2016; 12: 195-202
        View in Article
        • Donovan N.J.
        • Locascio J.J.
        • Marshall G.A.
        • Gatchel J.
        • Hanseeuw B.J.
        • Rentz D.M.
        • et al.
        Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults.
        Am J Psychiatry. 2018; 175: 530-537
        View in Article
        • Johansson M.
        • Stomrud E.
        • Lindberg O.
        • Westman E.
        • Johansson P.M.
        • van Westen D.
        • et al.
        Apathy and anxiety are early markers of Alzheimer’s disease.
        Neurobiol Aging. 2020; 85: 74-82
        View in Article
        • Hanseeuw B.J.
        • Jonas V.
        • Jackson J.
        • Betensky R.A.
        • Rentz D.M.
        • Johnson K.A.
        • et al.
        Association of anxiety with subcortical amyloidosis in cognitively normal older adults.
        Mol Psychiatry. 2020; 25: 2599-2607
        View in Article
        • Johansson M.
        • Stomrud E.
        • Insel P.S.
        • Leuzy A.
        • Johansson P.M.
        • Smith R.
        • et al.
        Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer’s disease.
        Transl Psychiatry. 2021; 11: 76
        View in Article
        • Mourao R.J.
        • Mansur G.
        • Malloy-Diniz L.F.
        • Castro Costa E.
        • Diniz B.S.
        Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: Systematic review and meta-analysis.
        Int J Geriatr Psychiatry. 2016; 31: 905-911
        View in Article
        • Johansson M.
        • Stomrud E.
        • Johansson P.M.
        • Svenningsson A.
        • Palmqvist S.
        • Janelidze S.
        • et al.
        Development of apathy, anxiety, and depression in cognitively unimpaired older adults: Effects of Alzheimer’s disease pathology and cognitive decline.
        Biol Psychiatry. 2022; 92: 34-43
        View in Article
        • Mori T.
        • Shimada H.
        • Shinotoh H.
        • Hirano S.
        • Eguchi Y.
        • Yamada M.
        • et al.
        Apathy correlates with prefrontal amyloid β deposition in Alzheimer’s disease.
        J Neurol Neurosurg Psychiatry. 2014; 85: 449-455
        View in Article
        • Jessen F.
        • Amariglio R.E.
        • Buckley R.F.
        • van der Flier W.M.
        • Han Y.
        • Molinuevo J.L.
        • et al.
        The characterisation of subjective cognitive decline.
        Lancet Neurol. 2020; 19: 271-278
        View in Article

      Article Info

      Publication History

      Accepted: April 25, 2022
      Received: April 22, 2022

      Identification

      DOI: https://doi.org/10.1016/j.biopsych.2022.04.013

      Copyright

      © 2022 Society of Biological Psychiatry.

      ScienceDirect

      Access this article on ScienceDirect

      Linked Article

      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2022 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX