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Metabolism Connects Body, Brain, and Behavior

      Metabolism connects body, brain, and behavior. To most people 20 years ago (and probably for many still today), this sentence was nothing more than a cliché that barely resonated with those interested in brain research or mental illness. It may sound esoteric or holistic in its lay meaning, with nothing substantive. However, the title “Metabolic Links Between Body, Brain, and Behavior” was chosen for this special issue of Biological Psychiatry because of the long unanswered and fundamentally crucial clinical issues of psychiatry that may be most directly, forcefully, and successfully addressed by adjusting the state-of-the-art study of the mind with that of metabolism. The reviews in this issue scratch the surface of the relationship between energy metabolism, obesity, eating disorders, and organizational principles of complex behaviors and their disorders. They demonstrate that there is increasing awareness that cellular and systemic principles of energy metabolism are crucial determinants of brain function.
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