Metabolism connects body, brain, and behavior. To most people 20 years ago (and probably
for many still today), this sentence was nothing more than a cliché that barely resonated
with those interested in brain research or mental illness. It may sound esoteric or
holistic in its lay meaning, with nothing substantive. However, the title “Metabolic
Links Between Body, Brain, and Behavior” was chosen for this special issue of Biological Psychiatry because of the long unanswered and fundamentally crucial clinical issues of psychiatry
that may be most directly, forcefully, and successfully addressed by adjusting the
state-of-the-art study of the mind with that of metabolism. The reviews in this issue
scratch the surface of the relationship between energy metabolism, obesity, eating
disorders, and organizational principles of complex behaviors and their disorders.
They demonstrate that there is increasing awareness that cellular and systemic principles
of energy metabolism are crucial determinants of brain function.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Positional cloning of the mouse obese gene and its human homologue.Nature. 1994; 372: 425-432
- Weight-reducing effects of the plasma protein encoded by the obese gene.Science. 1995; 269: 543-546
- Neurobiology of feeding end energy expenditure.Ann Rev Neurosci. 2007; 30: 367-398
- Monogenic obesity syndromes provide insights into the hypothalamic regulation of appetite and associated behaviors.Biol Psychiatry. 2022; 91: 856-859
- A neuroeconomics approach to obesity.Biol Psychiatry. 2022; 91: 860-868
- Higher-order inputs involved in appetite control.Biol Psychiatry. 2022; 91: 869-878
- Melanocortin signaling connecting systemic metabolism with mood disorders.Biol Psychiatry. 2022; 91: 879-887
- A framework for developing translationally relevant animal models of stress-induced changes in eating behavior.Biol Psychiatry. 2022; 91: 888-897
- Maternal metabolic programming of the developing central nervous system: Unified pathways to metabolic and psychiatric disorders.Biol Psychiatry. 2022; 91: 898-906
- Development of “hunger neurons” and the unanticipated relationship between energy metabolism and mother-infant interactions.Biol Psychiatry. 2022; 91: 907-914
Article Info
Publication History
Accepted:
March 24,
2022
Received in revised form:
March 23,
2022
Received:
March 22,
2022
Identification
Copyright
© 2022 Society of Biological Psychiatry.
