P602. Do Antipsychotics Suppress Cancer initiation? Identification of Novel off Target Effects of Typical Antipsychotics Using Epidemiology, Bioinformatics, and Protein-Kinase Activity

      Schizophrenia is a devastating psychiatric disorder that has a global prevalence of 1%. Interestingly, cancer rates in schizophrenia are lower than the general population. Previous epidemiological studies of cancer rates in schizophrenia did not fully account for confounding variables such as smoking and substance abuse. We sought to confirm lower cancer rates in schizophrenia and explore mechanisms responsible for this unexpected observation. We hypothesize that typical antipsychotics are competitive inhibitors of PIM kinases. We postulate that inhibition of PIM1 by antipsychotics accounts for reduced cancer incidence in schizophrenia.
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