Advertisement

P602. Do Antipsychotics Suppress Cancer initiation? Identification of Novel off Target Effects of Typical Antipsychotics Using Epidemiology, Bioinformatics, and Protein-Kinase Activity

      Schizophrenia is a devastating psychiatric disorder that has a global prevalence of 1%. Interestingly, cancer rates in schizophrenia are lower than the general population. Previous epidemiological studies of cancer rates in schizophrenia did not fully account for confounding variables such as smoking and substance abuse. We sought to confirm lower cancer rates in schizophrenia and explore mechanisms responsible for this unexpected observation. We hypothesize that typical antipsychotics are competitive inhibitors of PIM kinases. We postulate that inhibition of PIM1 by antipsychotics accounts for reduced cancer incidence in schizophrenia.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect