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P601. Kalrn Mutation Identified in Individuals With Schizophrenia Recapitulates Disease-Relevant Neuro-oscillatory Aberrations in the Mouse Visual and Prefrontal Cortices

      Aberrations in basic sensory cortical processing are present in several neuropsychiatric disorders. Electrophysiological biomarkers of sensory processing dysfunction can be reliably measured in both human patients and animal models, providing a translational strategy for linking molecular, circuit, and cognitive aspects of the disease. We recently developed a mouse model with a mutation in the Kalrn gene observed in a cohort of individuals with schizophrenia. These Kalrn-PT mice recapitulate structural changes in patients with schizophrenia, including adolescent-onset dendritic changes in the neocortex. Here we sought to understand how these structural changes may affect neural synchrony in local and interregional cortical circuits, focusing on a sensory processing paradigm with established disease relevance.
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