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P490. Repetitive Transcranial Magnetic Stimulation as a Probe of Episodic Memory Neurocircuitry in Schizophrenia

      Episodic memory (EM) is commonly impaired in schizophrenia. The precuneus is a key node in EM circuitry that has reciprocal connections with other EM relevant structures. Alterations in precuneus activity are associated with EM deficits in schizophrenia, though the exact mechanisms by which precuneus dysfunction is related to EM impairment is unclear. Repetitive transcranial magnetic stimulation (rTMS) enables direct manipulation of local brain activation and indirect manipulation of activation in the target’s associated neural networks. We examined effects of rTMS targeting the precuneus on function and connectivity of EM relevant circuitry in individuals with early phase psychosis.
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