P489. Cell-Type and Frequency-Specific Circuit for Mismatch Negativity in Mice

      Processing sensory information in line with concurrent context is disrupted in schizophrenia. Mismatch negativity (MMN) is an EEG event related potential that indexes how early sensory cortical responses differ to contextually unexpected events. Importantly, reduced auditory and visual MMN is a biomarker of schizophrenia. Despite this disease relevance, a circuit-level understanding of MMN generation is missing. Our past work in mouse visual cortex (V1) shows that the generation of a rodent analogue of MMN relies on both local interneurons and feedback input from higher areas of cortex. Here we sought to understand how such top-down and local circuitry interacts to process stimuli in context.
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