Psychedelics are rapidly gaining ground as an intervention of interest for severe
mood and anxiety disorders. The focus for most of this research is for patients who
have failed four or fewer adequate interventions. Few trials of any intervention have
looked at patients with depression who have failed more than four treatments in the
current episode. This is a pilot study looking at the open label administration of
25 mg of synthetic psilocybin in ten patients with documented failures of at least
five treatments in the current depressive episode.
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