Relationship of Striatal Presynaptic Dopamine to Midbrain Neuromelanin in a Nonhuman Primate Model of Maternal Immune Activation

      Maternal infection during pregnancy is a significant risk factor for future mental disorders in offspring. This phenomenon is studied translationally using maternal immune activation (MIA) models. Dopamine (DA) dysregulation is a feature of some MIA model systems. We previously reported increased striatal DA synthesis capacity in a pilot MIA NHP cohort. In the present study, we report data on the relationship between [18F] fluoro-l-m-tyrosine (FMT) PET measures in the striatum and substantia nigra (SN) neuromelanin (NM; a putative noninvasive proxy DA measure) levels in MIA NHP’s.
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