The molecular underpinnings of psychiatric disorders remain elusive despite there
being a paramount need to establish druggable targets for their treatment. Genome-wide
association studies (GWASs) have identified numerous candidate genes implicated in
the pathology of psychiatric disorders. However, a key challenge is to identify time
intervals when implicated biological pathways are germane. This information is critical
from a drug development perspective because it guides when psychopharmacotherapy should
be applied to achieve maximum effect.
SEE CORRESPONDING ARTICLE ON PAGE 399
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Developmental profile of psychiatric risk associated with voltage-gated cation channel activity.Biol Psychiatry. 2021; 90: 399-408
- Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission.Hum Genet. 2009; 125: 63-79
- Whole-genome association study of bipolar disorder.Mol Psychiatry. 2008; 13: 558-569
- CACNA1C (Cav1. 2) in the pathophysiology of psychiatric disease.Prog Neurobiol. 2012; 99: 1-14
- Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.Nat Genet. 2018; 50: 668-681
- Major channels involved in neuropsychiatric disorders and therapeutic perspectives.Front Genet. 2013; 4: 76
- Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder.Science. 2018; 362eaat8127
- Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain.Mol Psychiatry. 2020; 25: 37-47
- Targeted sequencing of 10,198 samples confirms abnormalities in neuronal activity and implicates voltage-gated sodium channels in schizophrenia pathogenesis.Biol Psychiatry. 2019; 85: 554-562
- Antidepressant-like effect of lamotrigine is reversed by veratrine: A possible role of sodium channels in bipolar depression.Behav Brain Res. 2008; 191: 49-54
Article info
Publication history
Accepted:
July 6,
2021
Received:
June 23,
2021
Identification
Copyright
© 2021 Society of Biological Psychiatry.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Developmental Profile of Psychiatric Risk Associated With Voltage-Gated Cation Channel ActivityBiological PsychiatryVol. 90Issue 6Open Access