Early Career Investigator Commentary| Volume 90, ISSUE 6, e31-e32, September 15, 2021

Critical Developmental Windows of Voltage-Gated Cation Channel Expression in Psychiatric Disorders

  • Noura Al-Juffali
    Address correspondence to Noura Al-Juffali, B.Sc., M.B.B.S., Ph.D., M.R.C.Psych.
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Oxford Health NHS Foundation Trust, Oxford, United Kingdom
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      The molecular underpinnings of psychiatric disorders remain elusive despite there being a paramount need to establish druggable targets for their treatment. Genome-wide association studies (GWASs) have identified numerous candidate genes implicated in the pathology of psychiatric disorders. However, a key challenge is to identify time intervals when implicated biological pathways are germane. This information is critical from a drug development perspective because it guides when psychopharmacotherapy should be applied to achieve maximum effect.
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