Profound cognitive deficits are a common feature of schizophrenia, and substantial impairments are also seen in bipolar disorder (BD) and major depressive disorder, albeit less frequently recognized. These impairments span the range of fluid intelligence functions, with the most severe tending to be in processing speed, working and episodic memory, and executive functioning, and can affect crystallized intelligence by reducing educational attainment. Cognitive deficits are highly correlated with impairments in the ability to perform everyday tasks, called functional capacity, affecting independence in residence, social capability, and employment, and thus directly contribute to the disability associated with these disorders.
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Accepted: June 25, 2021
Received: June 23, 2021
Published by Elsevier Inc on behalf of Society of Biological Psychiatry.
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- Genetic Overlap Profiles of Cognitive Ability in Psychotic and Affective Illnesses: A Multisite Study of Multiplex PedigreesBiological PsychiatryVol. 90Issue 6
- PreviewCognitive impairment is a key feature of psychiatric illness, making cognition an important tool for exploring of the genetics of illness risk. It remains unclear which measures should be prioritized in pleiotropy-guided research. Here, we generate profiles of genetic overlap between psychotic and affective disorders and cognitive measures in Caucasian and Hispanic groups.