Long considered promising targets for several neurological and psychiatric conditions,
metabotropic glutamate (mGlu) receptors present as many challenges as opportunities
for novel and effective therapeutic strategies. Eight subtypes of these G protein–coupled
receptors have so far been identified and are classified into three groups according
to their sequence homology, pharmacological properties, and downstream signaling pathways.
Group I (mGlu1 and mGlu5) couple to Gq proteins and largely have activating or facilitatory properties. Group II (mGlu2 and mGlu3) and group III (mGlu4, mGlu6, mGlu7, and mGlu8) couple to Gi/o proteins and generally have inhibitory signaling effects resulting in a decrease
of neurotransmitter release.
SEE CORRESPONDING ARTICLE ON PAGE 385
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References
- Targeting metabotropic glutamate receptors for novel treatments of schizophrenia.Mol Brain. 2017; 10: 15
- Meta-analysis supports GWAS-implicated link between GRM3 and schizophrenia risk.Transl Psychiatry. 2017; 7e1196
- Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic sites.Neuroscience. 2001; 106: 481-503
- Neuropharmacological insight from allosteric modulation of mGlu receptors.Trends Pharmacol Sci. 2019; 40: 240-252
- Activating mGlu3 metabotropic glutamate receptors rescues schizophrenia-like cognitive deficits through metaplastic adaptations within the hippocampus.Biol Psychiatry. 2021; 90: 385-398
- Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.Neuropharmacology. 2018; 128: 301-313
- Hippocampal metaplasticity is required for the formation of temporal associative memories.J Neurosci. 2014; 34: 16762-16773
- Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: A review.Curr Neuropharmacol. 2016; 14: 41-47
- AZD8529, a positive allosteric modulator at the mGluR2 receptor, does not improve symptoms in schizophrenia: A proof of principle study.Schizophr Res. 2016; 172: 152-157
- Subchronic phencyclidine treatment in adult mice increases GABAergic transmission and LTP threshold in the hippocampus.Neuropharmacology. 2016; 100: 90-97
Article info
Publication history
Accepted:
June 21,
2021
Received:
June 18,
2021
Identification
Copyright
© 2021 Society of Biological Psychiatry.
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Access this article on ScienceDirectLinked Article
- Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the HippocampusBiological PsychiatryVol. 90Issue 6
- PreviewPolymorphisms in GRM3, the gene encoding the mGlu3 metabotropic glutamate receptor, are associated with impaired cognition and neuropsychiatric disorders such as schizophrenia. Limited availability of selective genetic and molecular tools has hindered progress in developing a clear understanding of the mechanisms through which mGlu3 receptors regulate synaptic plasticity and cognition.
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