Long considered promising targets for several neurological and psychiatric conditions, metabotropic glutamate (mGlu) receptors present as many challenges as opportunities for novel and effective therapeutic strategies. Eight subtypes of these G protein–coupled receptors have so far been identified and are classified into three groups according to their sequence homology, pharmacological properties, and downstream signaling pathways. Group I (mGlu1 and mGlu5) couple to Gq proteins and largely have activating or facilitatory properties. Group II (mGlu2 and mGlu3) and group III (mGlu4, mGlu6, mGlu7, and mGlu8) couple to Gi/o proteins and generally have inhibitory signaling effects resulting in a decrease of neurotransmitter release.
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Accepted: June 21, 2021
Received: June 18, 2021
© 2021 Society of Biological Psychiatry.
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- Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the HippocampusBiological PsychiatryVol. 90Issue 6
- PreviewPolymorphisms in GRM3, the gene encoding the mGlu3 metabotropic glutamate receptor, are associated with impaired cognition and neuropsychiatric disorders such as schizophrenia. Limited availability of selective genetic and molecular tools has hindered progress in developing a clear understanding of the mechanisms through which mGlu3 receptors regulate synaptic plasticity and cognition.