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Longitudinal Changes of Local Field Potential Oscillations in Nucleus Accumbens and Anterior Limb of the Internal Capsule in Obsessive-Compulsive Disorder

  • Author Footnotes
    1 BX, RW, and YG contributed equally to this work.
    Botao Xiong
    Footnotes
    1 BX, RW, and YG contributed equally to this work.
    Affiliations
    Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China
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  • Author Footnotes
    1 BX, RW, and YG contributed equally to this work.
    Rong Wen
    Footnotes
    1 BX, RW, and YG contributed equally to this work.
    Affiliations
    Department of Neurosurgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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  • Author Footnotes
    1 BX, RW, and YG contributed equally to this work.
    Yuan Gao
    Footnotes
    1 BX, RW, and YG contributed equally to this work.
    Affiliations
    Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China
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  • Wei Wang
    Correspondence
    Address correspondence to Wei Wang, M.D.
    Affiliations
    Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China
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  • Author Footnotes
    1 BX, RW, and YG contributed equally to this work.
      Anterior limb of the internal capsule (ALIC) deep brain stimulation (DBS) shows stable efficacy in refractory obsessive-compulsive disorder (OCD) (
      • Graat I.
      • Mocking R.
      • Figee M.
      • Vulink N.
      • de Koning P.
      • Ooms P.
      • et al.
      Long term outcome deep brain stimulation of the ventral part of the anterior limb of the internal capsule in a cohort of 50 patients with treatment-refractory obsessive-compulsive disorder [published online ahead of print Aug 28].
      ). Recently, several DBS connectivity studies in OCD have investigated the effect of DBS on the structural and functional connectivity in the nucleus accumbens (NAc) and ALIC (
      • Li N.
      • Baldermann J.C.
      • Kibleur A.
      • Treu S.
      • Akram H.
      • Elias G.J.B.
      • et al.
      A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder.
      ,
      • Baldermann J.C.
      • Melzer C.
      • Zapf A.
      • Kohl S.
      • Timmermann L.
      • Tittgemeyer M.
      • et al.
      Connectivity profile predictive of effective deep brain stimulation in obsessive-compulsive disorder.
      ,
      • Tyagi H.
      • Apergis-Schoute A.M.
      • Akram H.
      • Foltynie T.
      • Limousin P.
      • Drummond L.M.
      • et al.
      A randomized trial directly comparing ventral capsule and anteromedial subthalamic nucleus stimulation in obsessive-compulsive disorder: Clinical and imaging evidence for dissociable effects.
      ,
      • Li N.
      • Hollunder B.
      • Baldermann J.C.
      • Kibleur A.
      • Treu S.
      • Akram H.
      • et al.
      A unified functional network target for deep brain stimulation in obsessive-compulsive disorder [published online ahead of print Apr 20].
      ). For electrophysiological effects, we attempt to examine the local effects of effective DBS in the NAc/ALIC by long-term recording the local field potentials (LFPs) in a case of OCD.
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