A Neurodevelopmental Perspective on Sex-Differentiated Genetic Effects on Behavior

  • Anna Gui
    Address correspondence to Anna Gui, Ph.D.
    Department of Psychological Sciences, Centre for Brain and Cognitive Development, Birkbeck, University of London, London, United Kingdom
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        • Martin J.
        • Khramtsova E.A.
        • Goleva S.B.
        • Blokland G.A.M.
        • Traglia M.
        • Walters R.K.
        • et al.
        Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits.
        Biol Psychiatry. 2021; 89: 1127-1137
        • Loomes R.
        • Hull L.
        • Mandy W.P.L.
        What is the male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis.
        J Am Acad Child Adolesc Psychiatry. 2017; 56: 466-474
        • Khramtsova E.A.
        • Davis L.K.
        • Stranger B.E.
        The role of sex in the genomics of human complex traits.
        Nat Rev Genet. 2019; 20: 173-190
        • Shi L.
        • Zhang Z.
        • Su B.
        Sex biased gene expression profiling of human brains at major developmental stages.
        Sci Rep. 2016; 6: 1-9
        • Werling D.M.
        • Parikshak N.N.
        • Geschwind D.H.
        Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders.
        Nat Commun. 2016; 7: 10717
        • McCarthy M.M.
        Multifaceted origins of sex differences in the brain.
        Philos Trans R Soc B Biol Sci. 2016; 371: 20150106
        • Spiers H.
        • Hannon E.
        • Schalkwyk L.C.
        • Smith R.
        • Wong C.C.Y.
        • Donovan M.C.O.
        • et al.
        Methylomic trajectories across human fetal brain development.
        Genome Res. 2015; 25: 338-352
        • Hines M.
        • Pasterski V.
        • Spencer D.
        • Neufeld S.
        • Patalay P.
        • Hindmarsh P.C.
        • et al.
        Prenatal androgen exposure alters girls’ responses to information indicating gender-appropriate behaviour.
        Philos Trans R Soc B Biol Sci. 2016; 371: 20150125
        • Polderman T.J.C.
        • Kreukels B.P.C.
        • Irwig M.S.
        • Beach L.
        • Chan Y.M.
        • Derks E.M.
        • et al.
        The biological contributions to gender identity and gender diversity: Bringing data to the table.
        Behav Genet. 2018; 48: 95-108
        • Warrier V.
        • Greenberg D.M.
        • Weir E.
        • Buckingham C.
        • Smith P.
        • Lai M.C.
        • et al.
        Elevated rates of autism, other neurodevelopmental and psychiatric diagnoses, and autistic traits in transgender and gender-diverse individuals.
        Nat Commun. 2020; 11: 3959

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