Advertisement

Propranolol Inhibits Reactivation of Fear Memory

      SEE CORRESPONDING ARTICLE ON PAGE 1150
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Kessler R.C.
        • Sonnega A.
        • Bromet E.
        • Hughes M.
        • Nelson C.B.
        Posttraumatic stress disorder in the National Comorbidity Survey.
        Arch Gen Psychiatry. 1995; 52: 1048-1060
        • Steenen S.A.
        • van Wijk A.J.
        • van der Heijden G.J.
        • van Westrhenen R.
        • de Lange J.
        • de Jongh A.
        Propranolol for the treatment of anxiety disorders: Systematic review and meta-analysis.
        J Psychopharmacol. 2016; 30: 128-139
        • Giustino T.F.
        • Fitzgerald P.J.
        • Maren S.
        Revisiting propranolol and PTSD: Memory erasure or extinction enhancement?.
        Neurobiol Learn Mem. 2016; 130: 26-33
        • Young C.
        • Butcher R.
        Propranolol for Post-Traumatic Stress Disorder: A Review of Clinical Effectiveness.
        Canadian Agency for Drugs and Technologies in Health, Ottawa, Ontario, Canada2020
        • Leal Santos S.
        • Stackmann M.
        • Muñoz Zamora A.
        • Mastrodonato A.
        • De Landri A.V.
        • Vaughan N.
        • et al.
        Propranolol decreases fear expression by modulating fear memory traces.
        Biol Psychiatry. 2021; 89: 1150-1161
        • Denny C.A.
        • Kheirbek M.A.
        • Alba E.L.
        • Tanaka K.F.
        • Brachman R.A.
        • Laughman K.B.
        • et al.
        Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis.
        Neuron. 2014; 83: 189-201
        • Debiec J.
        • Ledoux J.E.
        Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala.
        Neuroscience. 2004; 129: 267-272
        • Fitzgerald P.J.
        • Giustino T.F.
        • Seemann J.R.
        • Maren S.
        Noradrenergic blockade stabilizes prefrontal activity and enables fear extinction under stress.
        Proc Natl Acad Sci U S A. 2015; 112: E3729-E3737
        • Pitman R.K.
        • Sanders K.M.
        • Zusman R.M.
        • Healy A.R.
        • Cheema F.
        • Lasko N.B.
        • et al.
        Pilot study of secondary prevention of posttraumatic stress disorder with propranolol.
        Biol Psychiatry. 2002; 51: 189-192
        • Vaiva G.
        • Ducrocq F.
        • Jezequel K.
        • Averland B.
        • Lestavel P.
        • Brunet A.
        • et al.
        Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma.
        Biol Psychiatry. 2003; 54: 947-949

      Linked Article

      • Propranolol Decreases Fear Expression by Modulating Fear Memory Traces
        Biological PsychiatryVol. 89Issue 12
        • Preview
          Posttraumatic stress disorder can develop after a traumatic event and results in heightened, inappropriate fear and anxiety. Although approximately 8% of the U.S. population is affected by posttraumatic stress disorder, only two drugs have been approved by the Food and Drug Administration to treat it, both with limited efficacy. Propranolol, a nonselective β-adrenergic antagonist, has shown efficacy in decreasing exaggerated fear, and there has been renewed interest in using it to treat fear disorders.
        • Full-Text
        • PDF