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Cortical and Subcortical Brain Morphometry Abnormalities in Youth at Clinical High Risk for Psychosis and Individuals With Early Illness Schizophrenia

      Many longitudinal structural brain imaging studies have reported progressive worsening of morphometric brain abnormalities in schizophrenia over the illness course, consistent with an underlying progressive pathophysiology. Although morphometric abnormalities in chronic schizophrenia are well-documented, less is known about brain morphometry abnormalities prior to psychosis onset in individuals at clinical high risk for psychosis (CHR), and how they compare with abnormalities early in the course of schizophrenia (ESZ).
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