Many longitudinal structural brain imaging studies have reported progressive worsening
of morphometric brain abnormalities in schizophrenia over the illness course, consistent
with an underlying progressive pathophysiology. Although morphometric abnormalities
in chronic schizophrenia are well-documented, less is known about brain morphometry
abnormalities prior to psychosis onset in individuals at clinical high risk for psychosis
(CHR), and how they compare with abnormalities early in the course of schizophrenia
(ESZ).
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© 2021 Published by Elsevier Inc.
