Fibroblast growth factor 2(FGF2) is a growth factor involved in the pathophysiology
of major depression.FGF-antisense (FGF-AS), the natural antisense transcript of FGF2,
is indicated in the regulation of FGF2 expression. We previously reported that hippocampal
overexpression of FGF-AS resulted in depression-like behaviour, whereas FGF-AS knockdown
had antidepressant and anxiolytic effects, which both were independent of changes
in FGF2 protein levels. To have an insight into the mechanism of actions of FGF-AS
protein, we investigated the effects of manipulations of FGF-AS expression on hippocampal
neurogenesis, as there are many studies suggesting the involvement of neurogenesis
in the regulation of affective behaviour.
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