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Effect of FGF-AS Modulation on Neurogenesis in Rat Hippocampus

      Fibroblast growth factor 2(FGF2) is a growth factor involved in the pathophysiology of major depression.FGF-antisense (FGF-AS), the natural antisense transcript of FGF2, is indicated in the regulation of FGF2 expression. We previously reported that hippocampal overexpression of FGF-AS resulted in depression-like behaviour, whereas FGF-AS knockdown had antidepressant and anxiolytic effects, which both were independent of changes in FGF2 protein levels. To have an insight into the mechanism of actions of FGF-AS protein, we investigated the effects of manipulations of FGF-AS expression on hippocampal neurogenesis, as there are many studies suggesting the involvement of neurogenesis in the regulation of affective behaviour.
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