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Respiratory Related Oscillations in Cortex and Hippocampus in the Acute Ketamine Model of Schizophrenia in Rats

      Breathing in rodents normally overlaps with delta and theta oscillations involved in oscillatory coupling between prefrontal cortex (PFC) and hippocampus (HC). Recent studies reported that the respiratory rhythm (RR), mediated by the olfactory bulb (OB) through monitoring nasal air movement, may promote synchronous brain oscillations globally, including higher-order brain networks, such as PFC and HC. On the other hand, Ketamine, known to elicit schizophrenia-like symptoms, strongly disturb EEG oscillations which was proposed to contribute to cognitive deficits in both schizophrenia and after Ketamine administration.
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