Autoimmune encephalitis is an important differential diagnosis in psychiatry, especially
for psychotic or neurocognitive syndromes (
1
). Novel neuronal autoantibodies with yet unknown target antigens could be essential
in this context (
2
). Recently, overlaps between autoimmune and neurodegenerative mechanisms have been
described in neurology, paradigmatically in anti-IgLON5 encephalopathy (
3
). The rationale of the current study is to present a patient with a neuropsychiatric
syndrome, Huntington’s disease (HD), and novel neuronal autoantibodies.- Sabater L.
- Gaig C.
- Gelpi E.
- Bataller L.
- Lewerenz J.
- Torres-Vega E.
- et al.
A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing
disorder associated with antibodies to IgLON5: A case series, characterisation of
the antigen, and post-mortem study.
Lancet Neurol. 2014; 13: 575-586
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References
- Autoimmune psychosis: An international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin.Lancet Psychiatry. 2020; 7: 93-108
- Probable autoimmune catatonia with antibodies against cilia on hippocampal granule cells and highly suspicious cerebral FDG-positron emission tomography findings.Biol Psychiatry. 2020; 87: e29-e31
- A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: A case series, characterisation of the antigen, and post-mortem study.Lancet Neurol. 2014; 13: 575-586
- Diagnosing organic causes of schizophrenia spectrum disorders: Findings from a one-year cohort of the Freiburg Diagnostic Protocol in Psychosis (FDPP).Diagnostics (Basel). 2020; 10: E691
- A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model.Cell. 2020; 183: 1058-1069.e19
- Huntington's disease: From molecular pathogenesis to clinical treatment.Lancet Neurol. 2011; 10: 83-98
- IgA autoantibodies against native myelin basic protein in a patient with MS.Neurol Neuroimmunol Neuroinflamm. 2019; 6: e569
- Antimyelin basic protein and antimyelin antibody-producing cells in multiple sclerosis.Ann Neurol. 1990; 27: 132-136
- High prevalence of NMDA receptor IgA/IgM antibodies in different dementia types.Ann Clin Transl Neurol. 2014; 1: 822-832
- Parkinsonian syndrome with frontal lobe involvement and anti-glycine receptor antibodies.Brain Sci. 2020; 10: 399
- Effects of IgLON5 antibodies on neuronal cytoskeleton: A link between autoimmunity and neurodegeneration.Ann Neurol. 2020; 88: 1023-1027
Article info
Publication history
Published online: March 12, 2021
Accepted:
December 21,
2020
Received in revised form:
December 19,
2020
Received:
November 14,
2020
Identification
Copyright
© 2021 Society of Biological Psychiatry.
