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Novel Neuronal Autoantibodies in Huntington’s Disease

  • Dominique Endres
    Affiliations
    Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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  • Rita Werden
    Affiliations
    Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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  • Tina Schweizer
    Affiliations
    Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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  • Nils Schröter
    Affiliations
    Department for Neurology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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  • Miriam A. Schiele
    Affiliations
    Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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  • Kathrin Nickel
    Affiliations
    Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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  • Maike Fischer
    Affiliations
    Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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  • Katharina Domschke
    Affiliations
    Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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  • Horst Urbach
    Affiliations
    Department of Neuroradiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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  • Philipp T. Meyer
    Affiliations
    Department of Nuclear Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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  • Author Footnotes
    1 HP and LTvE contributed equally to this work as joint senior authors.
    Harald Prüss
    Footnotes
    1 HP and LTvE contributed equally to this work as joint senior authors.
    Affiliations
    Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany

    German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany
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  • Author Footnotes
    1 HP and LTvE contributed equally to this work as joint senior authors.
    Ludger Tebartz van Elst
    Correspondence
    Address correspondence to Ludger Tebartz van Elst, M.D.
    Footnotes
    1 HP and LTvE contributed equally to this work as joint senior authors.
    Affiliations
    Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
    Search for articles by this author
  • Author Footnotes
    1 HP and LTvE contributed equally to this work as joint senior authors.
      Autoimmune encephalitis is an important differential diagnosis in psychiatry, especially for psychotic or neurocognitive syndromes (
      • Pollak T.A.
      • Lennox B.R.
      • Müller S.
      • Benros M.E.
      • Prüss H.
      • Tebartz van Elst L.
      • et al.
      Autoimmune psychosis: An international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin.
      ). Novel neuronal autoantibodies with yet unknown target antigens could be essential in this context (
      • Endres D.
      • Prüss H.
      • Rauer S.
      • Süß P.
      • Venhoff N.
      • Feige B.
      • et al.
      Probable autoimmune catatonia with antibodies against cilia on hippocampal granule cells and highly suspicious cerebral FDG-positron emission tomography findings.
      ). Recently, overlaps between autoimmune and neurodegenerative mechanisms have been described in neurology, paradigmatically in anti-IgLON5 encephalopathy (
      • Sabater L.
      • Gaig C.
      • Gelpi E.
      • Bataller L.
      • Lewerenz J.
      • Torres-Vega E.
      • et al.
      A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: A case series, characterisation of the antigen, and post-mortem study.
      ). The rationale of the current study is to present a patient with a neuropsychiatric syndrome, Huntington’s disease (HD), and novel neuronal autoantibodies.
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