Commentary| Volume 89, ISSUE 5, P419-420, March 01, 2021

The When and Where: Molecular and Cellular Convergence in Autism

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Geschwind D.H.
        • State M.W.
        Gene hunting in autism spectrum disorder: On the path to precision medicine.
        Lancet Neurol. 2015; 14: 1109-1120
        • Quesnel-Vallières M.
        • Weatheritt R.J.
        • Cordes S.P.
        • Blencowe B.J.
        Autism spectrum disorder: Insights into convergent mechanisms from transcriptomics.
        Nat Rev Genet. 2019; 20: 51-63
        • Donovan A.P.A.
        • Basson M.A.
        The neuroanatomy of autism – a developmental perspective.
        J Anat. 2017; 230: 4-15
        • Mariani J.
        • Coppola G.
        • Zhang P.
        • Abyzov A.
        • Provini L.
        • Tomasini L.
        • et al.
        FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders.
        Cell. 2015; 162: 375-390
        • Marchetto M.C.
        • Belinson H.
        • Tian Y.
        • Freitas B.C.
        • Fu C.
        • Vadodaria K.C.
        • et al.
        Altered proliferation and networks in neural cells derived from idiopathic autistic individuals.
        Mol Psychiatry. 2017; 22: 820-835
        • Schafer S.T.
        • Paquola A.C.M.
        • Stern S.
        • Gosselin D.
        • Ku M.
        • Pena M.
        • et al.
        Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons.
        Nat Neurosci. 2019; 22: 243-255
        • Griesi-Oliveira K.
        • Fogo M.S.
        • Pinto B.G.G.
        • Alves A.Y.
        • Suzuki A.M.
        • Morales A.G.
        • et al.
        Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder [published online ahead of print Feb 14].
        Mol Psychiatry. 2020;
        • DeRosa B.A.
        • El Hokayem J.
        • Artimovich E.
        • Garcia-Serje C.
        • Phillips A.W.
        • Van Booven D.
        • et al.
        Convergent pathways in idiopathic autism revealed by time course transcriptomic analysis of patient-derived neurons.
        Sci Rep. 2018; 8: 8423
        • Gazestani V.H.
        • Pramparo T.
        • Nalabolu S.
        • Kellman B.P.
        • Murray S.
        • Lopez L.
        • et al.
        A perturbed gene network containing PI3K–AKT, RAS–ERK and WNT–β-catenin pathways in leukocytes is linked to ASD genetics and symptom severity.
        Nat Neurosci. 2019; 22: 1624-1634
        • Adhya D.
        • Swarup V.
        • Nagy R.
        • Dutan L.
        • Shum C.
        • Valencia-Alarcón E.P.
        • et al.
        Atypical neurogenesis in induced pluripotent stem cells from autistic individuals.
        Biol Psychiatry. 2021; 89: 486-496

      Linked Article

      • Atypical Neurogenesis in Induced Pluripotent Stem Cells From Autistic Individuals
        Biological PsychiatryVol. 89Issue 5
        • Preview
          Autism is a heterogeneous collection of disorders with a complex molecular underpinning. Evidence from postmortem brain studies have indicated that early prenatal development may be altered in autism. Induced pluripotent stem cells (iPSCs) generated from individuals with autism with macrocephaly also indicate prenatal development as a critical period for this condition. But little is known about early altered cellular events during prenatal stages in autism.
        • Full-Text
        • PDF
        Open Access