A recent report by DeGroot et al. (
1
) described how ventral tegmental area dopamine engages dopamine D1 receptor–expressing neurons in the caudal interpeduncular nucleus that innervate
ventral neuronal populations of this nucleus, thereby amplifying the ventral tegmental
area signal to modulate certain aspects of behavior in mice in the commonly used elevated
plus maze and open field tests. Reported experiments employed cutting-edge technologies
to deliver a convincing set of results.To read this article in full you will need to make a payment
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References
- Midbrain dopamine controls anxiety-like behavior by engaging unique interpeduncular nucleus microcircuitry.Biol Psychiatry. 2020; 88: 855-866
- Do animal models of anxiety predict anxiolytic-like effects of antidepressants?.Psychopharmacology (Berl). 2002; 163: 121-141
- Is delay of reward mediated by shock-avoidance behavior a critical target for anti-punishment effects of diazepam in rats?.Psychopharmacology (Berl). 1985; 87: 473-479
- Selective serotonin reuptake inhibitors decrease impulsive behavior as measured by an adjusting delay procedure in the pigeon.Neuropsychopharmacology. 2002; 27: 421-429
- Ventral striatal D2/3 receptor availability is associated with impulsive choice behavior as well as limbic corticostriatal connectivity.Int J Neuropsychopharmacol. 2018; 21: 705-715
- Brexpiprazole reduces hyperactivity, impulsivity, and risk-preference behavior in mice with dopamine transporter knockdown-a model of mania.Psychopharmacology (Berl). 2017; 234: 1017-1028
Article Info
Publication History
Published online: February 18, 2021
Accepted:
December 18,
2020
Received:
November 20,
2020
Identification
Copyright
© 2020 Society of Biological Psychiatry.
