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Brain Amyloid Deposition in Late-Life Depression

Published:November 11, 2020DOI:https://doi.org/10.1016/j.biopsych.2020.07.025
      We read with great interest the recent article by Mackin et al. (
      • Mackin R.S.
      • Insel P.S.
      • Landau S.
      • Bickford D.
      • Morin R.
      • Rhodes E.
      • et al.
      Late-life depression is associated with reduced cortical amyloid burden: Findings from the Alzheimer’s Disease Neuroimaging Initiative Depression Project.
      ). This is an important contribution because it reverts the common belief that subjects with late-life depression (LLD) have increased brain amyloid beta (Aβ) deposition compared with cognitively healthy nondepressed (ND) control subjects. Indeed, the authors found that patients with LLD have less Aβ pathology than control subjects. Mackin et al. confirmed previous literature showing that this psychiatric population has impaired cognition and speculated that this may be due to Aβ-unrelated mechanisms. The study appears robust because it involved 238 subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Depression Project and ADNI database. However, we would like to point out some potential biases of the study that may have influenced the findings, at least in part.
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