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Article info
Publication history
Accepted:
July 27,
2020
Received:
July 24,
2020
Identification
Copyright
© 2020 Society of Biological Psychiatry.
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Access this article on ScienceDirectLinked Article
- Modular, Circuit-Based Interventions Rescue Hippocampal-Dependent Social and Spatial Memory in a 22q11.2 Deletion Syndrome Mouse ModelBiological PsychiatryVol. 88Issue 9
- Preview22q11.2 deletion syndrome (22qDS) manifests with myriad symptoms, including multiple neuropsychiatric disorders. Complications associated with the polygenic haploinsufficiency make 22qDS symptoms particularly difficult to manage with traditional therapeutic approaches. However, the varying mechanistic consequences often culminate to generate inappropriate regulation of neuronal circuit activity. We explored whether managing this aberrant activity in adults could be a therapeutically beneficial strategy.
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