To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Biological Psychiatry
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.Psychol Rev. 1992; 99: 195-231
- Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia.Trends Neurosci. 2008; 31: 234-242
- Neurobiology of depression.Neuron. 2002; 34: 13-25
- Are the dorsal and ventral hippocampus functionally distinct structures?.Neuron. 2010; 65: 7-19
- DREADDs for neuroscientists.Neuron. 2016; 89: 683-694
- Modular, circuit-based interventions rescue hippocampal-dependent social and spatial memory in a 22q11.2 deletion syndrome mouse model.Biol Psychiatry. 2020; 88: 710-718
- The molecular genetics of the 22q11-associated schizophrenia.Brain Res Mol Brain Res. 2004; 132: 95-104
- Antipsychotic drugs rapidly induce dopamine neuron depolarization block in a developmental rat model of schizophrenia.J Neurosci. 2011; 31: 12330
- Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner.Nat Commun. 2019; 10: 2819
- Neural synchrony in brain disorders: Relevance for cognitive dysfunctions and pathophysiology.Neuron. 2006; 52: 155-168
Accepted: July 27, 2020
Received: July 24, 2020
© 2020 Society of Biological Psychiatry.
ScienceDirectAccess this article on ScienceDirect
- Modular, Circuit-Based Interventions Rescue Hippocampal-Dependent Social and Spatial Memory in a 22q11.2 Deletion Syndrome Mouse ModelBiological PsychiatryVol. 88Issue 9
- Preview22q11.2 deletion syndrome (22qDS) manifests with myriad symptoms, including multiple neuropsychiatric disorders. Complications associated with the polygenic haploinsufficiency make 22qDS symptoms particularly difficult to manage with traditional therapeutic approaches. However, the varying mechanistic consequences often culminate to generate inappropriate regulation of neuronal circuit activity. We explored whether managing this aberrant activity in adults could be a therapeutically beneficial strategy.