Adult hippocampal neurogenesis (AHN) is a phenomenon by which the brain responds to
biological and environmental clues by producing new neurons in selected brain regions
of adult mammals, including humans (
1
,
2
). There has been an ongoing debate regarding the presence of AHN in humans and about
the role that adult-born neurons might have in cognition and behavior (
3
). Functions related to AHN are dependent not just on neurogenesis per se, but on
the ability of newborn neurons to survive, differentiate, and integrate in the dentate
gyrus (DG) circuit.
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References
- Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease.Nat Med. 2019; 25: 554-560
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- Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine.Pharmacol Biochem Behav. 2020; 188: 172837
- Chronic pain impairs memory formation via disruption of neurogenesis mediated by mesohippocampal brain-derived neurotrophic factor signaling.Biol Psychiatry. 2020; 88: 597-610
- Antidepressants recruit new neurons to improve stress response regulation.Mol Psychiatry. 2011; 16: 1177-1188
- Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis.Cell Tissue Res. 2018; 371: 33-46
- Improvement of PTSD-like behavior by the forgetting effect of hippocampal neurogenesis enhancer memantine in a social defeat stress paradigm.Mol Brain. 2019; 12: 68
- Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation.Nature. 2011; 472: 466-470
Article info
Publication history
Accepted:
July 29,
2020
Received:
July 27,
2020
Identification
Copyright
© 2020 Society of Biological Psychiatry.
