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The Many Avenues Leading to Adult Neurogenesis Adaptations

      Adult hippocampal neurogenesis (AHN) is a phenomenon by which the brain responds to biological and environmental clues by producing new neurons in selected brain regions of adult mammals, including humans (
      • Moreno-Jimenez E.P.
      • Flor-Garcia M.
      • Terreros-Roncal J.
      • Rabano A.
      • Cafini F.
      • Pallas-Bazarra N.
      • et al.
      Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease.
      ,
      • Boldrini M.
      • Fulmore C.A.
      • Tartt A.N.
      • Simeon L.R.
      • Pavlova I.
      • Poposka V.
      • et al.
      Human hippocampal neurogenesis persists throughout aging.
      ). There has been an ongoing debate regarding the presence of AHN in humans and about the role that adult-born neurons might have in cognition and behavior (
      • Augusto-Oliveira M.
      • Arrifano G.P.F.
      • Malva J.O.
      • Crespo-Lopez M.E.
      Adult hippocampal neurogenesis in different taxonomic groups: Possible functional similarities and striking controversies.
      ). Functions related to AHN are dependent not just on neurogenesis per se, but on the ability of newborn neurons to survive, differentiate, and integrate in the dentate gyrus (DG) circuit.
      SEE CORRESPONDING ARTICLE ON PAGE 597
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      References

        • Moreno-Jimenez E.P.
        • Flor-Garcia M.
        • Terreros-Roncal J.
        • Rabano A.
        • Cafini F.
        • Pallas-Bazarra N.
        • et al.
        Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease.
        Nat Med. 2019; 25: 554-560
        • Boldrini M.
        • Fulmore C.A.
        • Tartt A.N.
        • Simeon L.R.
        • Pavlova I.
        • Poposka V.
        • et al.
        Human hippocampal neurogenesis persists throughout aging.
        Cell Stem Cell. 2018; 22: 589-599.e5
        • Augusto-Oliveira M.
        • Arrifano G.P.F.
        • Malva J.O.
        • Crespo-Lopez M.E.
        Adult hippocampal neurogenesis in different taxonomic groups: Possible functional similarities and striking controversies.
        Cells. 2019; 8: 125
        • Fournier N.M.
        • Lee B.
        • Banasr M.
        • Elsayed M.
        • Duman R.S.
        Vascular endothelial growth factor regulates adult hippocampal cell proliferation through MEK/ERK- and PI3K/Akt-dependent signaling.
        Neuropharmacology. 2012; 63: 642-652
        • Deyama S.
        • Duman R.S.
        Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine.
        Pharmacol Biochem Behav. 2020; 188: 172837
        • Xia S.-H.
        • Hu S.-W.
        • Ge D.-G.
        • Liu D.
        • Wang D.
        • Zhang S.
        • et al.
        Chronic pain impairs memory formation via disruption of neurogenesis mediated by mesohippocampal brain-derived neurotrophic factor signaling.
        Biol Psychiatry. 2020; 88: 597-610
        • Surget A.
        • Tanti A.
        • Leonardo E.D.
        • Laugeray A.
        • Rainer Q.
        • Touma C.
        • et al.
        Antidepressants recruit new neurons to improve stress response regulation.
        Mol Psychiatry. 2011; 16: 1177-1188
        • Catavero C.
        • Bao H.
        • Song J.
        Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis.
        Cell Tissue Res. 2018; 371: 33-46
        • Ishikawa R.
        • Uchida C.
        • Kitaoka S.
        • Furuyashiki T.
        • Kida S.
        Improvement of PTSD-like behavior by the forgetting effect of hippocampal neurogenesis enhancer memantine in a social defeat stress paradigm.
        Mol Brain. 2019; 12: 68
        • Sahay A.
        • Scobie K.N.
        • Hill A.S.
        • O’Carroll C.M.
        • Kheirbek M.A.
        • Burghardt N.S.
        • et al.
        Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation.
        Nature. 2011; 472: 466-470

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